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What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

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No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Intervention not reported

Time to resolution of clinical signs and symptoms [days] · adults and children with clinical signs and symptoms of acute lower respiratory tract infection
1 finding from 1 review

Intermittent 'as needed' ICS vs daily ICS

Change from baseline mean daily use of β2‐agonists (puffs/day) (duration 24 to 44 weeks) · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in change from baseline mean daily use of β2‐agonists (puffs/day)… compared with daily ICS (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of bad physical health days in past 30 days · working‐age adults

It is very uncertain whether the intervention changes number of bad physical health days in past 30 days (very low certainty).

1 finding from 1 review

Intervention not reported

Mental health/psychological distress Number of bad mental health days in past 30 days · working‐age adults

It is very uncertain whether the intervention changes mental health/psychological distress Number of bad mental health… (very low certainty).

1 finding from 1 review

Intervention not reported

One day of piperacillin, cefazolin, cefmetazole, or cefotiam versus three days of piperacillin, cefazolin, cefmetazole, or cefotiam (elective colorectal surgery) · surgical patients

It is very uncertain whether the intervention changes one day of piperacillin, cefazolin, cefmetazole, or cefotiam versus… (very low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Global state: 2. Requiring 3 or more injections ‐ over 7 days · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE may leads to lower global state: 2. Requiring 3 or more injections ‐ over 7 days compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Diarrhoea · patients symptomatic for NTS infection

It is very uncertain whether antibiotics changes presence of diarrhoea at 2‐4 days compared with placebo or no treatment (very low certainty).

2 findings from 1 review

Any ICS plus oral corticosteroid vs oral corticosteroid

Asthma relapse1at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in asthma relapse1at 20 to 24 days compared with oral corticosteroid (high certainty).

1 finding from 1 review

Any ICS plus oral corticosteroid vs oral corticosteroid

Hoarseness at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in hoarseness at 20 to 24 days compared with oral corticosteroid (moderate certainty).

1 finding from 1 review