Cochrane · systematic review · CD009557
Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery
Sajid, MS, Hutson, KH, Rapisarda, IFF, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fibrin glue instillation under skin flaps compared to no‐fibrin for breast and axillary surgery
Population: people with breast and axillary surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of postoperativeseromaRR Fibrin glue instillation under skin flaps vs no‐fibrin | RR 1.02 [0.9, 1.16] | 18 studies · 1252 participants | Low Downgraded: risk of bias |
Mean volume of seromaSMD Fibrin glue instillation under skin flaps vs no‐fibrin | no estimate extracted | 10 studies · 731 participants | Low Downgraded: risk of bias |
Total volume of drained seromaSMD Fibrin glue instillation under skin flaps vs no‐fibrin | no estimate extracted | 13 studies · 888 participants | Low Downgraded: risk of bias |
Number of days for persistent drainageSMD Fibrin glue instillation under skin flaps vs no‐fibrin | no estimate extracted | 13 studies · 861 participants | Low Downgraded: risk of bias |
Surgical site infectionRR Fibrin glue instillation under skin flaps vs no‐fibrin | RR 1.05 [0.63, 1.77] | 13 studies · 1009 participants | Low Downgraded: risk of bias |
PostoperativecomplicationsRR Fibrin glue instillation under skin flaps vs no‐fibrin | RR 1.13 [0.63, 2.04] | 11 studies · 981 participants | Low Downgraded: risk of bias |
Length of hospital staySMD Fibrin glue instillation under skin flaps vs no‐fibrin | no estimate extracted | 6 studies · 364 participants | Low Downgraded: risk of bias |