Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Platelet rich fibrin showed no clear difference in presence of dry socket compared with control; GRADE not reported.
1 finding from 1 review
Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
3 trials reported no adverse events. 1 study reported adverse events (alterations in taste, bad taste, staining) in 24/62 in chlorhexidine group versus 0/40 in placebo group, Peto OR = 8.42 (95% CI 3.31 to 21.39). A…
6 studies
GRADE not reported
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review
MRONJ (incidence proportion) · People treated with oral bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review
In both study arms, no case of postoperative MRONJ was observed (700 participants; 1 RCT); effect not estimable.
1 study · 700 participants
GRADE not reported
Healing of MRONJ · People with established (manifest) MRONJ
It is very uncertain whether bone morphogenetic protein-2 (BMP-2) together with platelet-rich… changes healing of MRONJ compared with platelet-rich fibrin alone (very low certainty).
1 finding from 1 review
Pain (VAS 0-10) · Adults (>18 years) with established dry socket following permanent tooth extraction
It is very uncertain whether zinc oxide eugenol changes pain (VAS 0-10) compared with alvogyl (old formulation) (very low certainty).
1 finding from 1 review
Healing of MRONJ · People with established (manifest) MRONJ
It is very uncertain whether hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy changes healing of MRONJ compared with conventional therapy (very low certainty).
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Chlorhexidine rinse (0.2%) pre- and post-extraction showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%) post-extraction only; GRADE not reported.
1 finding from 1 review
Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction
Neocone led to lower time to complete resolution of pain (days) compared with zinc oxide eugenol; GRADE not reported.
1 finding from 1 review
MRONJ (incidence proportion) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)
It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence proportion) compared with standard care (very low certainty).
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Metronidazole gel (25%, intrasocket) showed no clear difference in presence of dry socket compared with placebo gel; GRADE not reported.
1 finding from 1 review
Self‐reported shoulder function: Croft Shoulder Disability Score (1 or more problems) · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)
It is very uncertain whether early changes self‐reported shoulder function: Croft Shoulder Disability Score (1… compared with delayed mobilisation (very low certainty).
2 findings from 1 review
Functional outcomes · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical showed no clear difference in functional scoresf(higher = better outcome) compared with non‐surgical treatment (high certainty).
3 findings from 1 review
SMD 0.06
5 studies · 423 participants
High
SMD 0.1
7 studies · 552 participants
High
SMD 0.17
3 studies · 347 participants
Moderate
Quality of life: EQ‐5D (0: dead to 1: best quality of life) · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical showed no clear difference in quality of life: EQ‐5D (0: dead to 1: best quality of life) compared with non‐surgical treatment (high certainty).
1 finding from 1 review
All‐cause mortality · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical showed no clear difference in mortality compared with non‐surgical treatment (low certainty).
1 finding from 1 review
Reoperation · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical may leads to higher additional surgery (reoperation or secondary surgery) compared with non‐surgical treatment (low certainty).
1 finding from 1 review
Adverse events / complications ‐ Number of participants with complications · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical showed no clear difference in adverse events / complications ‐ Number of participants with… compared with non‐surgical treatment (low certainty).
1 finding from 1 review
Self‐reported shoulder function · adults undergoing surgery for displaced proximal humeral fracturesa (2 trials)
Locking plate showed no clear difference in self‐reported shoulder function: functional scoresb(higher = better… compared with locking intramedullary nail (low certainty).
3 findings from 1 review
SMD 0.15
4 studies · 227 participants
Low
no estimate extracted
3 studies · 174 participants
Low
no estimate extracted
2 studies · 101 participants
Low
Quality of life: SF‐36 (0 to 100: best outcome) · adults undergoing surgery for displaced proximal humeral fracturesa (2 trials)
1 finding from 1 review