Question · asked by 1 review
Bone morphogenetic protein-2 (BMP-2) together with platelet-rich fibrin vs Platelet-rich fibrin (PRF): Healing of MRONJ
- Population
- People with established (manifest) MRONJ
- Intervention
- Bone morphogenetic protein-2 (BMP-2) together with platelet-rich fibrin
- Comparison
- Platelet-rich fibrin (PRF)
- Outcome
- Healing of MRONJ
It is very uncertain whether bone morphogenetic protein-2 (BMP-2) together with platelet-rich… changes healing of MRONJ compared with platelet-rich fibrin alone (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Bone morphogenetic protein-2 (BMP-2) together with platelet-rich fibrin vs Platelet-rich fibrin alone Healing of MRONJ · People with established (manifest) MRONJ · 16 weeks It is very uncertain whether bone morphogenetic protein-2 (BMP-2) together with platelet-rich… changes healing of MRONJ compared with platelet-rich fibrin alone (very low certainty). Interventions for managing medication‐related osteonecrosis of the jaw (2022) · Cochrane All outcomes | RR 1.10 [0.94, 1.29] | 1 study · 55 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes | 2021-06 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.