Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Summary of findings: Defibrotide vs no treatment

All‐cause mortality at 100 days post‐transplant · Children undergoing stem cell transplant with malignant and non‐malignant diseases and risk factors for hepatic veno‐occlusive disease

Summary of findings: Defibrotide showed no clear difference in all‐cause mortality at 100 days post‐transplant ( compared with no treatment (low certainty).

1 finding from 1 review

Glutamine vs placebo

All‐cause mortality at 100 days post‐transplant · People undergoing stem cell transplant with haematological malignancies

It is very uncertain whether summary of findings: Glutamine changes all‐cause mortality at 100 days post‐transplant ( compared with placebo (very low certainty).

1 finding from 1 review

Ursodeoxycholic acid vs placebo or no treatment

All‐cause mortality at 100 days post‐transplant · Patients undergoing stem cell transplant with malignant and non‐malignant diseases

Summary of findings: Ursodeoxycholic acid may leads to lower all‐cause mortality at 100 days post‐transplant ( compared with placebo or no treatment (low certainty).

1 finding from 1 review

Heparin vs no treatment

All‐cause mortality at 100 days post‐transplant · People undergoing autologous or HLA identical allogeneic bone marrow transplant with a variety of malignant diseases or aplastic anaemia

Summary of findings: Heparin showed no clear difference in all‐cause mortality at 100 days post‐transplant ( compared with no treatment (low certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: intermediate‐term (3 to 4 days) Subjective severity score · patients with common cold

Antihistamines showed no clear difference in change in severity of overall symptoms: intermediate‐term (3 to 4… compared with placebo (high certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score · patients with common cold

Antihistamines showed no clear difference in change in severity of overall symptoms: long‐term (6 to 10 days)… compared with placebo (high certainty).

1 finding from 1 review

Sedating antihistamines vs placebo

Change in severity of overall symptoms: short‐term (1 to 2 days) Subjective severity score · patients with common cold

Sedating antihistamines leads to lower change in severity of overall symptoms: short‐term (1 to 2 days)… compared with placebo (high certainty).

1 finding from 1 review

Sedating antihistamines vs placebo

Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score · patients with common cold

Sedating antihistamines showed no clear difference in change in severity of overall symptoms: long‐term (6 to 10 days)… compared with placebo (high certainty).

1 finding from 1 review

Planned early birth vs expectant management

Perinatal mortality (stillbirth ‐ death of fetus prior to birth; neonatal death ‐ death within the first 28 days of birth; or infant death ‐ death after the first 28 days) · pregnant women with a term suspected compromised baby
1 finding from 1 review

Intervention not reported

Number of subjects who develop any adverse event (42 days to 10 months) · adults with asymptomatic bacteriuria

The intervention probably leads to higher number of subjects who develop any adverse event (42 days to 10… (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of subjects with bacteriological cure (42 days to 4 years) · adults with asymptomatic bacteriuria

The intervention probably leads to higher number of subjects with bacteriological cure (42 days to 4 years) (moderate certainty).

1 finding from 1 review

Tacrolimus 0.03% vs corticosteroids

Physician's assessment of global response of improvement, clear or excellent ‐ 6 weeks · people with atopic dermatitis

Tacrolimus 0.03% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty).

4 findings from 1 review
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Tacrolimus 0.03% vs corticosteroids

Participant's self‐assessment of global response of improvement: tacrolimus 0.03% 2x/day versus hydrocortisone acetate 1% 2x/day · people with atopic dermatitis

Tacrolimus 0.03% probably leads to higher participant's self‐assessment of global response of improvement:… compared with corticosteroids (moderate certainty).

1 finding from 1 review