Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

929 questions · 946 findings · 295 reviews · Headline outcomes only

No studies found 150 · 15.9%GRADE not reported 47 · 5%Very low 312 · 33%Low 262 · 27.7%Moderate 138 · 14.6%High 37 · 3.9%

Rituximab vs placebo

CAS improvement (decrease) by 2 or more points · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes CAS improvement (decrease) by 2 or more points compared with placebo (very low certainty).

1 finding from 1 review

Rituximab vs placebo

NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 classes or more compared with placebo (very low certainty).

1 finding from 1 review

Binocular iPad treatment vs occlusion therapy

Measurable change in stereopsis after 8 (± 2) weeks and 16 (± 2) weeks of intervention 'Real change' in stereopsis is defined as a change in stereoacuity of two or more octaves. · 5‐ to 8‐year‐old children with amblyopia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise vs control

Number of people who experienced one or more falls · people with Parkinson's disease

Summary of findings for exercise showed no clear difference in number of people who experienced one or more falls compared with control (moderate certainty).

1 finding from 1 review

Summary of findings for exercise plus education vs control

Number of people sustaining one or more fall‐related fractures · people with Parkinson's disease

It is very uncertain whether summary of findings for exercise plus education changes number of people sustaining one or more fall‐related fractures compared with control (very low certainty).

1 finding from 1 review

Exercise vs control

Number of people sustaining one or more fall‐related fractures · people with Parkinson's disease

It is very uncertain whether summary of findings for exercise changes number of people sustaining one or more fall‐related fractures compared with control (very low certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Clinician‐reported signs of eczema: number of participants with one or more relapses (16‐20 weeks) · children and adults with mild to severe eczema

Weekend therapy probably leads to lower clinician‐reported signs of eczema: number of participants with one… compared with no topical corticosteroid (moderate certainty).

1 finding from 1 review

Cemented vs uncemented hemiarthroplasty

Mobility, early (within 4 months): able to walk outdoors using no more than 1 walking aid. · adults with displaced and undisplaced hip fractures

Cemented showed no clear difference in mobility, early (within 4 months): able to walk outdoors using no… compared with uncemented hemiarthroplasty (moderate certainty).

1 finding from 1 review

Vitrectomy vs vitreous tap biopsy and antibiotic injection

Improvement in visual acuity at 3 months' · people with endophthalmitis following intraocular surgery

It is very uncertain whether vitrectomy changes proportion of people with a visual acuity improvement of 10 letters… compared with vitreous tap biopsy and antibiotic injection (very low certainty).

1 finding from 1 review