Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,304 questions · 1,352 findings · 210 reviews

No studies found 230 · 17%GRADE not reported 163 · 12.1%Very low 269 · 19.9%Low 277 · 20.5%Moderate 291 · 21.5%High 122 · 9%

G‐CSF vs placebo or no treatment

Oral mucositis (moderate to severe) · Adults with cancer receiving treatment

It is very uncertain whether granulocyte-colony stimulating factor (G-CSF) changes oral mucositis (moderate to severe) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse outcomes ‐ corneal haze score at 12 months (grade 1.0 ‐ more prominent haze that does not interfere with visibility of fine iris details; grade 2.0 ‐ mild obscuration of iris details; grade 3.0 ‐ moderate obscuration of iris and lens; and ... · adult participants (≥ 18 years) with myopia
1 finding from 1 review

Oxycodone MR vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review

Oral hydromorphone vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Moderate benefit: at least 30% reduction in pain, or PGIC much or very much improved · Adults with chronic neuropathic pain
1 finding from 1 review

Pregabalin vs placebo

Maintenance of initial therapeutic response of at least 30% pain intensity reduction over baseline and continued treatment at 13 or 26 weeks (equivalent to 'moderate benefit') · adults with fibromyalgia enrolled in EERW studies
1 finding from 1 review

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

Episodes of pain (moderate or high pain; six-face rating scale) · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) may leads to lower episodes of pain (moderate or high pain; six-face rating scale) compared with conventional mechanical caries removal (standard drill; handpiece… (low certainty).

1 finding from 1 review