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What do systematic reviews say?

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Evidence found and GRADE certainty

781 questions · 829 findings · 43 reviews · Headline outcomes only

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No studies found 215 · 25.9%GRADE not reported 39 · 4.7%Very low 205 · 24.7%Low 208 · 25.1%Moderate 130 · 15.7%High 32 · 3.9%

Engagement of community leaders vs usual care

Proportion of children who received DTP3 or Penta 3 by 1 year of age · children under 5 years of age

Engagement of community leaders probably leads to higher proportion of children who received DTP3 or Penta 3 by 1 year of age compared with routine care (moderate certainty).

1 finding from 1 review

Intervention not reported

Breast cancer stage at the time of presentation: defined as the proportion of women with breast cancer diagnosed at early stage (stage 0, I, II) Time of outcome assessment: 3 years to 20 years Method of measurement: CBE · health workers

The intervention may leads to higher breast cancer stage at the time of presentation: defined as the… (low certainty).

1 finding from 1 review

Intervention not reported

Breast cancer stage at the time of presentation: defined as the proportion of women with breast cancer diagnosed at late stage (stage III, IV) Time of outcome assessment: 3 years to 20 years Method of measurement: CBE · health workers

The intervention may leads to lower breast cancer stage at the time of presentation: defined as the… (low certainty).

1 finding from 1 review

Intervention not reported

Breast cancer mortality: defined as deaths among women who received a diagnosis of breast cancer Time of outcome assessment: 3 years to 20 years Method of measurement: death registration offices, hospital records, and house visits · health workers

It is very uncertain whether the intervention changes breast cancer mortality: defined as deaths among women who received… (very low certainty).

1 finding from 1 review

Brief intervention vs brief advice, information, or assessment only

Harmful alcohol use · people with hazardous or harmful alcohol consumption
2 findings from 1 review

Any Psychosocial intervention plus pharm vs psychosocial interventions

Harmful alcohol use · alcohol use disorder
2 findings from 1 review

Any Psychosocial intervention plus pharm vs psychosocial interventions

Retention [ · alcohol use disorder

Pharmacologic intervention along with psychosocial intervention showed no clear difference in retention compared with psychosocial intervention alone (moderate certainty).

1 finding from 1 review

Pharmacologic intervention vs another pharmacologic intervention

Harmful alcohol use ‐ not measured · alcohol use disorder

The review found no eligible studies for this question.

2 findings from 1 review

Pharmacologic intervention vs another pharmacologic intervention

Retention [ · alcohol use disorder

Pharmacologic intervention showed no clear difference in retention compared with another pharmacologic intervention (low certainty).

2 findings from 1 review

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Diagnosis of mental disorders at study endpoint · preventing mental disorders
2 findings from 1 review