GCF elastase activity and non-surgical periodontal treatment outcome (salivary cortisol, ICTP measured; no effect reported) · Adults with periodontitis needing non-surgical periodontal treatment
In one 6-month longitudinal study, patients under psychosocial stress had higher gingival crevicular fluid elastase and poorer outcomes after non-surgical periodontal therapy; not pooled (ungraded).
1 finding from 1 review
Gingival inflammation and GCF IL-1β IL-6 and IL-8 · Adults with gingivitis or periodontitis from a private periodontics practice
Perceived stress was associated with IL-1β IL-6 and IL-8 levels in gingival crevicular fluid.
1 finding from 1 review
Periodontitis and GCF IL-6 · Women on long-term sick leave for depression
Depressed women had higher periodontal disease and GCF IL-6 after adjustment for age and smoking.
1 finding from 1 review
Remineralisation of early enamel caries · Patients (mainly children) with white spot lesions (WSL)
Professionally applied 5% sodium fluoride varnish remineralised about two-thirds of early enamel caries lesions in children (pooled proportion 63.6%, 95% CI 36.0% to 91.2%; 4 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).
1 finding from 1 review
Arrest of dentine caries · Children with active dentine caries
One randomised trial found nano-silver fluoride arrested dentine caries without the black staining seen with silver diamine fluoride; ungraded.
1 finding from 1 review
Intervention not reported
Remineralisation of early enamel caries
1 finding from 1 review
Dimensional change (size) of early enamel caries lesions · Patients (mainly children) with white spot lesions (WSL)
In one trial, professionally applied sodium fluoride varnish significantly reduced the size of early enamel caries lesions compared with no fluoride treatment; ungraded.
1 finding from 1 review
Arrest of dentine caries · Children with dentine caries in primary and permanent teeth
Professionally applied 38% silver diamine fluoride arrested about two-thirds of active dentine caries surfaces in children (pooled proportion 65.9%, 95% CI 41.2% to 90.7%; 5 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).
1 finding from 1 review
Periodontitis and allostatic load · US adults in NHANES III
Allostatic load partly explained socioeconomic gradients in periodontal disease.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Intervention not reported
Arrest of dentine caries
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported
Antibody titres to periodontal pathogens · Adults with periodontitis
In one case-control study, depression as a marker of social isolation was associated with elevated antibody titres to periodontal pathogens at baseline and 1-year follow-up; not pooled (ungraded).
1 finding from 1 review
Periodontitis and allostatic load · US adults in NHANES 1999-2004
Allostatic load increased the probability of periodontitis and the association varied by race/ethnicity.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Development of carious lesions on sealed occlusal pits and fissures · Children with fully erupted permanent first molar teeth (mean age about 6 to 8 years)
At 48 months, no statistically significant difference was found between HVGIC and resin-based sealants (RR 0.62, 95% CI 0.31 to 1.21); evidence ungraded and at high risk of bias.
4 findings from 1 review
RR 0.62 [0.31, 1.21]
2 studies · 1007 evaluated sealed teeth participants
GRADE not reported
RR 0.29 [0.09, 0.95]
2 studies · 205 evaluated sealed teeth participants
GRADE not reported
RR 0.90 [0.49, 1.67]
3 studies · 600 evaluated sealed teeth participants
GRADE not reported
Show 1 more finding
Intervention not reported
Dental caries prevalence in primary teeth (cavitated lesions) · Children aged 5-6 years in Latin America and the Caribbean
In other Latin American/Caribbean countries, pooled primary-teeth caries prevalence was 70% (95% CI 59-79%), significantly higher than Brazil (p=0.002); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence in permanent teeth (cavitated lesions) · Children aged 11-13 years in Latin America and the Caribbean
In other Latin American/Caribbean countries, pooled permanent-teeth caries prevalence was 64% (95% CI 45-79%), not significantly different from Brazil (p=0.42); certainty not graded.
1 finding from 1 review
Intervention not reported
Serum inflammatory cytokines (IL-1b, IL-6) and cortisol in periodontitis
1 finding from 1 review
Remineralisation of early enamel caries · Children with early (incipient) enamel caries
One trial found acidulated phosphate fluoride gel did not remineralise early enamel caries; ungraded.
1 finding from 1 review
Proportion of dentists utilizing SE/SW for deep carious lesions · Dentists managing deep carious lesions in permanent vital teeth
Across nine surveys of 4199 dentists, a pooled 53% (95% CI 44% to 62%) chose selective or stepwise (evidence-based) carious tissue removal for deep lesions in permanent teeth, with very high heterogeneity (I2=96%) and no formal certainty rating (ungraded).
1 finding from 1 review
Intervention not reported
Dental caries prevalence in primary teeth (cavitated lesions) · Children aged 5-6 years in Latin America and the Caribbean
In Brazil, pooled primary-teeth caries prevalence in 5-6 year-olds was 52% (95% CI 49-54%); certainty not graded.
1 finding from 1 review
Remineralisation of early enamel caries · Children with early (incipient) enamel caries
One trial found sodium fluoride gel significantly remineralised early enamel caries; ungraded.
1 finding from 1 review