Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,667 questions · 21,760 findings · 2,177 reviews

No studies found 4,173 · 19.2%GRADE not reported 2,300 · 10.6%Very low 5,276 · 24.2%Low 5,764 · 26.5%Moderate 3,298 · 15.2%High 949 · 4.4%

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Antihypertensive drug therapy vs placebo

Number of cases of dementia Range of · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia

It is very uncertain whether antihypertensive therapy changes number of cases of dementia Range of compared with placebo (very low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Adverse events Study reports · adults with Major Depressive Disorder

It is very uncertain whether n3PUFAs changes adverse eventsStudy reports compared with placebo (very low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Quality of lifeValidated quality of life scales as used by authors, CGI (7‐point scale) where possible, higher scores indicate poorer quality of life · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Trial non‐completionStudy reports · adults with Major Depressive Disorder

It is very uncertain whether n3PUFAs changes trial non‐completionStudy reports compared with placebo (very low certainty).

1 finding from 1 review