Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · All outcomes

No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Preterm birth (oral health / enamel defects) vs Full-term children

Caries (DMFT) and enamel defects · Preterm children (about 8 years old) in the United Arab Emirates (Dubai)

One study found preterm children had higher DMFT and a fourfold higher prevalence of enamel defects than full-term children (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Oral prednisone plus curcuminoids (adjunctive) vs Oral prednisone plus placebo

Reduction in pain · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Osteoporosis with pathological fracture · European-ancestry adults

In multivariable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.279, not significant).

2 findings from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Osteoporosis · European-ancestry adults

In multivariable MR (adjusted for periodontitis), higher genetically predicted dental caries (DMFS) causally increased osteoporosis risk (OR 1.165, moderate evidence).

2 findings from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Bone mineral density in forearm · European-ancestry adults

Genetically predicted dental caries (DMFS) had no causal effect on forearm BMD.

1 finding from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Lumbar spine and pelvis fracture · European-ancestry adults

Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of lumbar spine and pelvis (multivariable MR, OR 0.968).

2 findings from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Forearm fracture · European-ancestry adults

Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of forearm (multivariable MR, OR 0.973).

2 findings from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)

In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence).

2 findings from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Femoral neck bone mineral density (FN-BMD) · European-ancestry adults

Genetically predicted dental caries (DMFS) had no causal effect on femoral neck BMD.

1 finding from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Femur fracture · European-ancestry adults

Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of femur (multivariable MR, OR 1.069).

2 findings from 1 review

Acupressure at P6 point with thumb plus sedation vs Sham (dummy) acupressure with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with thumb plus sedation changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Acupressure at P6 point with thumb plus sedation vs Sham (dummy) acupressure with sedation

Adverse effects · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Acupressure at P6 point with thumb plus sedation vs Sham (dummy) acupressure with sedation

Completion of dental treatment · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with thumb plus sedation changes completion of dental procedure compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Acupressure at P6 point with device plus sedation vs Sham (dummy) acupressure with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with device plus sedation changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Acupressure at P6 point with device plus sedation vs Sham (dummy) acupressure with sedation

Completion of dental treatment · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with device plus sedation changes completion of dental procedure compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Acupressure at P6 point with device plus sedation vs Sham (dummy) acupressure with sedation

Adverse effects · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Overall survival · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Patients' quality of life · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Delay in start of radiation treatment · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review