Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Ibuprofen vs placebo

At least 50% reduction in pain · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen changes number of participants with at least 50% pain relief at 4 hours compared with placebo (very low certainty).

2 findings from 1 review

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

Number of participants reporting an adverse event · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants reporting or experiencing any adverse event compared with active comparator (acetaminophen) (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

At least 50% reduction in pain · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants with at least 50% pain relief at 4 hours compared with active comparator (acetaminophen) (very low certainty).

2 findings from 1 review

Intervention not reported

Change in anxiety · various, including general population, pregnant people, psychiatric populations (ADHD, alcohol use disorder, anxiety disorder, depression,…
1 finding from 1 review

Intervention not reported

Change in depression · various, including general population, pregnant people, psychiatric populations (ADHD, alcohol use disorder, anxiety disorder, depression,…
1 finding from 1 review

Intervention not reported

Mixed anxiety and depression · various, including general population, pregnant people, psychiatric populations (ADHD, alcohol use disorder, anxiety disorder, depression,…
1 finding from 1 review