Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

IPL (with/without MGX) vs no treatment/sham

Corneal sodium fluorescein staining, measured using a validated clinical scale, at 3 months of · people with meibomian gland dysfunction

It is very uncertain whether IPL (with/without MGX) changes corneal sodium fluorescein staining, measured using a validated… compared with sham or no treatment (with/without MGX) (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality at longest · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes mortality at longest (very low certainty).

1 finding from 1 review

Intervention not reported

Requirement for renal replacement therapy ( · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes requirement for renal replacement therapy ( (very low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at… compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Severe maternal morbidity and mortality index · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in severe maternal morbidity and mortality index compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pregnancy loss or stillbirth at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pregnancy loss or stillbirth at any gestational age compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Caesarean section · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in caesarean section compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium vs placebo (offspring outcomes) commencing before or early

Low birthweight · women who are not yet pregnant and women in the early stages of pregnancy

Calcium showed no clear difference in birthweight < 2500 g compared with placebo (offspring outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium vs placebo (offspring outcomes) commencing before or early

Apgar score less than 7 at 5 minutes · women who are not yet pregnant and women in the early stages of pregnancy

It is very uncertain whether calcium changes apgar < 7 at 5 minutes compared with placebo (offspring outcomes) commencing before or early (very low certainty).

1 finding from 1 review

Calcium vs placebo (offspring outcomes) commencing before or early

Perinatal death, or NICU admission for > 24 hours (or both) · women who are not yet pregnant and women in the early stages of pregnancy

Calcium showed no clear difference in perinatal death, or NICU admission for > 24 hours (or both) compared with placebo (offspring outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium vs placebo (offspring outcomes) commencing before or early

Pregnancy loss, stillbirth or neonatal death before discharge · women who are not yet pregnant and women in the early stages of pregnancy

Calcium showed no clear difference in pregnancy loss, stillbirth or NND before discharge compared with placebo (offspring outcomes) commencing before or early (low certainty).

1 finding from 1 review