Progression‐free survival · people with single or solitary brain metastasis
Surgery plus whole brain radiotherapy (WBRT) showed no clear difference in progression‐free survival compared with stereotactic radiosurgery plus WBRT (low certainty).
1 finding from 1 review
Overall survival · patients with asymptomatic, incurable, metastatic colorectal cancer
Delayed chemotherapy showed no clear difference in overall survival compared with immediate chemotherapy (low certainty).
1 finding from 1 review
Nausea and vomiting · patients with asymptomatic, incurable, metastatic colorectal cancer
It is very uncertain whether delayed chemotherapy changes toxicity – nausea and vomiting compared with immediate chemotherapy (very low certainty).
1 finding from 1 review
Toxicity – stomatitis · patients with asymptomatic, incurable, metastatic colorectal cancer
It is very uncertain whether delayed chemotherapy changes toxicity – stomatitis compared with immediate chemotherapy (very low certainty).
1 finding from 1 review
Toxicity – diarrhoea · patients with asymptomatic, incurable, metastatic colorectal cancer
It is very uncertain whether delayed chemotherapy changes toxicity – diarrhoea compared with immediate chemotherapy (very low certainty).
1 finding from 1 review
Quality of life · patients with asymptomatic, incurable, metastatic colorectal cancer
1 finding from 1 review
Progression‐free survival · patients with asymptomatic, incurable, metastatic colorectal cancer
1 finding from 1 review
Chemotherapy compliance · patients with asymptomatic, incurable, metastatic colorectal cancer
1 finding from 1 review
Complete clearance · people with scabies, 2 to 80 years of ageLocation: India, Pakistan
Oral ivermectin 200 μg/kg (1 to 3 doses) may leads to lower complete clearance ‐ week 1 compared with topical permethrin 5% cream (1 to 3 applications) (low certainty).
5 findings from 1 review
RR 0.65 [0.54, 0.78]
6 studies · 613 participants
Low
RR 0.91 [0.76, 1.08]
5 studies · 459 participants
Low
RR 1 [0.86, 1.16]
1 study · 80 participants
High
Show 2 more findings
Complete clearance · people with scabies, 5 to 60 years of ageLocation: Egypt, Pakistan
Oral ivermectin 200 μg/kg (1 to 2 doses) showed no clear difference in complete clearance ‐ week 1 ‐ IVER 1 dose versus PER on 5… compared with topical permethrin 5% lotion (1 to 5 applications) (low certainty).
4 findings from 1 review
RR 0.7 [0.47, 1.03]
1 study · 107 participants
Low
RR 1 [0.78, 1.29]
1 study · 120 participants
Low
RR 0.97 [0.81, 1.17]
1 study · 107 participants
Moderate
Show 1 more finding
Number of participants with ≥ 1 AE ‐ week 2 ‐ IVER 2 doses versus PER on 5 consecutive nights · people with scabies, 5 to 60 years of ageLocation: Egypt, Pakistan
It is very uncertain whether oral ivermectin 200 μg/kg (1 to 2 doses) changes number of participants with ≥ 1 AE ‐ week 2 ‐ IVER 2 doses versus… compared with topical permethrin 5% lotion (1 to 5 applications) (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with scabies, 5 to 60 years of ageLocation: Egypt, Pakistan
1 finding from 1 review
Complete clearance · people with scabies, 5 to 80 years of ageLocation: India
Topical ivermectin 1% lotion (1 to 3 applications) showed no clear difference in complete clearance ‐ week 4 compared with topical permethrin 5% cream (1 to 3 applications) (moderate certainty).
1 finding from 1 review
Number of participants with ≥ 1 AE ‐ week 4 · people with scabies, 5 to 80 years of ageLocation: India
It is very uncertain whether topical ivermectin 1% lotion (1 to 3 applications) changes number of participants with ≥ 1 AE ‐ week 4 compared with topical permethrin 5% cream (1 to 3 applications) (very low certainty).
1 finding from 1 review
Number of participants with ≥ 1 AE ‐ week 2 · people with scabies, 2 to 80 years of ageLocation: India, Pakistan
1 finding from 1 review
Number of participants with ≥ 1 AE ‐ week 4 · people with scabies, 2 to 80 years of ageLocation: India, Pakistan
Oral ivermectin 200 μg/kg (1 to 3 doses) showed no clear difference in number of participants with ≥ 1 AE ‐ week 4 compared with topical permethrin 5% cream (1 to 3 applications) (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with scabies, 2 to 80 years of ageLocation: India, Pakistan
1 finding from 1 review
Intervention not reported
Leukopenia** grade 3 or 4 (safety population) · women with metastatic breast cancer
The intervention probably leads to higher leukopenia** grade 3 or 4 (safety population) (moderate certainty).
1 finding from 1 review
Intervention not reported
Overall survival ‐ trials of mTNBC participants · women with metastatic triple‐negative breast cancer (mTNBC)
The intervention showed no clear difference in overall survival ‐ trials of mTNBC participants (low certainty).
1 finding from 1 review
Intervention not reported
Progression‐free survival/time to progression (randomised participants) ‐ trials of mTNBC participants · women with metastatic triple‐negative breast cancer (mTNBC)
The intervention may leads to lower progression‐free survival/time to progression (randomised… (low certainty).
1 finding from 1 review