Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications): Complete clearance
Oral ivermectin 200 μg/kg (1 to 3 doses) may leads to lower complete clearance ‐ week 1 compared with topical permethrin 5% cream (1 to 3 applications) (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) Complete clearance ‐ week 1 · people with scabies, 2 to 80 years of ageLocation: India, Pakistan Oral ivermectin 200 μg/kg (1 to 3 doses) may leads to lower complete clearance ‐ week 1 compared with topical permethrin 5% cream (1 to 3 applications) (low certainty). Ivermectin and permethrin for treating scabies (2018) · Cochrane Headline outcomes only | RR 0.65 [0.54, 0.78] | 6 studies · 613 participants | Low |
Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) Complete clearance ‐ week 2 · people with scabies, 2 to 80 years of ageLocation: India, Pakistan Oral ivermectin 200 μg/kg (1 to 3 doses) showed no clear difference in complete clearance ‐ week 2 compared with topical permethrin 5% cream (1 to 3 applications) (low certainty). Ivermectin and permethrin for treating scabies (2018) · Cochrane Headline outcomes only | RR 0.91 [0.76, 1.08] | 5 studies · 459 participants | Low |
Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) Complete clearance ‐ week 4 ‐ IVER 1 dose versus PER 1 application · people with scabies, 2 to 80 years of ageLocation: India, Pakistan Oral ivermectin 200 μg/kg (1 to 3 doses) showed no clear difference in complete clearance ‐ week 4 ‐ IVER 1 dose versus PER 1 application compared with topical permethrin 5% cream (1 to 3 applications) (high certainty). Ivermectin and permethrin for treating scabies (2018) · Cochrane Headline outcomes only | RR 1 [0.86, 1.16] | 1 study · 80 participants | High |
Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) Complete clearance ‐ week 4 ‐ IVER 1 to 3 doses versus PER 1 to 3 applications · people with scabies, 2 to 80 years of ageLocation: India, Pakistan Oral ivermectin 200 μg/kg (1 to 3 doses) showed no clear difference in complete clearance ‐ week 4 ‐ IVER 1 to 3 doses versus PER 1 to 3… compared with topical permethrin 5% cream (1 to 3 applications) (low certainty). Ivermectin and permethrin for treating scabies (2018) · Cochrane Headline outcomes only | RR 0.92 [0.82, 1.03] | 5 studies · 581 participants | Low |
Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) Complete clearance ‐ week 4 ‐ IVER 2 doses versus PER 1 application · people with scabies, 2 to 80 years of ageLocation: India, Pakistan Oral ivermectin 200 μg/kg (1 to 3 doses) showed no clear difference in complete clearance ‐ week 4 ‐ IVER 2 doses versus PER 1 application compared with topical permethrin 5% cream (1 to 3 applications) (high certainty). Ivermectin and permethrin for treating scabies (2018) · Cochrane Headline outcomes only | RR 0.97 [0.83, 1.14] | 1 study · 80 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Ivermectin and permethrin for treating scabies 2018 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.