Periapical pathosis · Vital teeth restored with indirect restorations
Periapical pathosis incidence among follow-up >5-10 years was 3.88% (subgroup analysis; not GRADE-rated).
6 findings from 1 review
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Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration significantly improved remineralization versus control (SMD -0.94, 95% CI -1.46 to -0.43), ranking second of seven therapies by SUCRA (88.7%); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Oral health-related quality of life · Indian children aged 3-5 years
In children aged 3-5 years, early childhood caries was significantly associated with poorer OHRQoL (narrative; 3 studies); ungraded.
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Fluoride varnish did not differ significantly from CPP-ACP (SMD -0.07, 95% CI -0.44 to 0.29); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
CA VI concentration · Individuals assessed for dental caries (mainly children aged 2-9 years; one study in adults aged 18-24 years)
Salivary CA VI concentration is significantly lower in individuals with dental caries than in caries-free individuals (SMD -0.672, 95% CI -1.011 to -0.332; not GRADE-rated).
1 finding from 1 review
Cariogenic bacteria (Lactobacilli colony count) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Long-term (>=12 months) fluoride mouthwash may make little or no difference to Lactobacilli colony counts versus blank control (very low certainty).
1 finding from 1 review
Oral mucosal moisture · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
One small study found that chewing hard (but not soft) gum increased oral mucosal moisture.
1 finding from 1 review
CA VI activity · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
CA VI activity was higher in participants with caries (SMD 0.87, 95% CI 0.39 to 1.36; 7 studies, 411 participants); GRADE was not reported.
1 finding from 1 review
Oral health-related quality of life · Indian elderly and general-population adults
Prosthetic need was significantly associated with poorer OHRQoL in both included studies (moderate certainty).
3 findings from 1 review
Prosthetic need vs none: both included studies showed a significant association with poor QoL (Nagarajappa 2015, Shivakumar 2018); 950 participants, 2 observational studies; Moderate certainty (Fig 1 GRADE SoF). No…
2 studies · 950 participants
Moderate
Prosthetic need and QoL (continuous, OHIP-14): prosthetic need was significantly related to various components of OHRQoL (Joseph 2016). Single study, not pooled.
1 study
GRADE not reported
Prosthetic need and QoL (continuous, GOHAI): of three studies, one found no significant difference (Shetty 2013) and two proved the association (Pillai 2015, Rekhi 2018). Not pooled.
3 studies
GRADE not reported
Severity of white spot lesions (surface area and depth) · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
White spot lesion severity was assessed narratively in a small number of studies and not meta-analyzed; evidence is limited (ungraded).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 2 or more years in permanent teeth, secondary caries did not differ significantly between fluoride-containing amalgam and GIC (RR 0.95, 95% CI 0.45-2.00; low certainty).
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · Indians
Prosthetic need is associated with poor OHRQoL (moderate certainty).
1 finding from 1 review
Adverse events (participants with >=1 adverse event) · Adults with Parkinson's disease and sialorrhea (drooling)
Type A botulinum toxin showed a borderline, non-significant increase in adverse events versus placebo (RD 0.10, 95% CI 0.00 to 0.21; ungraded subgroup).
3 findings from 1 review
Oral health-related quality of life · Indian children and young adults
Two studies found dental fluorosis significantly associated with poorer OHRQoL; narrative, ungraded.
1 finding from 1 review
Dental fluorosis and QoL (continuous, OIDP/CPQ11-14): a significant difference between individuals with and without fluorosis on OHRQoL (Nagarajappa 2015, Shyam 2020). Two studies, 3000 individuals; not pooled.
2 studies · 3000 participants
GRADE not reported
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
Over 2 or more years in deciduous teeth, secondary caries did not differ significantly between resin composite and RMGIC (RR 1.60, 95% CI 0.85-3.00; low certainty).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
In deciduous teeth at 1 year, secondary caries did not differ significantly between compomer and resin composite, with high heterogeneity (RR 0.41, 95% CI 0.02-8.34; I2=83%; ungraded).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Combined self-assembling peptide P11-4 plus fluoride varnish significantly improved white spot lesion remineralization versus control (SMD -0.96, 95% CI -1.44 to -0.48) and ranked highest of seven therapies by SUCRA (89.7%); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Gingival index (GI) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Chlorhexidine mouthwash may reduce the Gingival Index versus blank control in the short term (WMD -0.54, 95% CI -0.96 to -0.13), but with very high heterogeneity the evidence is very uncertain (very low certainty).
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with > 5–10 years of follow-up was 5.53%.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy
For pulpotomy, whether MTA improves success over calcium hydroxide is uncertain (OR 2.36, 95% CI 0.47-11.75; low certainty; CI includes no effect).
1 finding from 1 review