Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,587 questions · 5,761 findings · 495 reviews

No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Intermittent ICS vs placebo

Exacerbations requiring oral corticosteroids ‐ School‐age children · School‐aged children and adults

Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ School‐age children compared with placebo (low certainty).

1 finding from 1 review

Vitamin D vs placebo or control

Femoral neck bone mineral density (FN-BMD) · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in femoral neck, Community-dwelling adults: WMD 1.10 (95% CI 0.40 to 1.90), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Methotrexate vs placebo

Maintenance of clinical remission · Participants with Crohn's disease in remission

Methotrexate showed no clear difference in proportion of patients maintaining clinical remission (low dose oral… compared with placebo (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs control

Number of participants with worsening scores in corporal atrophy · people with pre‐malignant lesions

Proton pump inhibitor showed no clear difference in number of participants with worsening scores in corporal atrophy compared with control (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs control

Number of participants with worsening scores in corporal intestinal metaplasia · people with pre‐malignant lesions

Proton pump inhibitor showed no clear difference in number of participants with worsening scores in corporal intestinal… compared with control (low certainty).

1 finding from 1 review

Intervention not reported

Asthma exacerbation as defined by hospital admission or treatment with a course of oral corticosteroids · participants with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Asthma exacerbation as defined by hospital admission or treatment with a course of oral corticosteroids · participants with exercise‐induced asthma

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride varnish vs placebo or no treatment

Adverse effects / specific side effects (oral allergic reactions, mucosal irritation, adverse symptoms such as nausea, gagging, vomiting) · Children and adolescents aged 16 years or less
1 finding from 1 review

Intervention not reported

Oral anticoagulants: time in target INR range (%) · patients with leading physiological parameters within therapeutic range
1 finding from 1 review

Intervention not reported

Time to achieve therapeutic range ‐ oral anticoagulants: time to achieve therapeutic prothrombin ratio (days) · patients with reducing time to achieve therapeutic control
1 finding from 1 review