Search review questions

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · Coverage: Not covering

OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies

Composite: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration · Continent: South America

Odds of higher caries (DMFT) category · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022) · Cross-sectional (survey data 2011-2022), Human Development Index (ordinal logistic regression, adjusted)

Absence of wear · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities) · 2 years

Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Across edentulism prevalence categories

Aesthetics as a factor of choice · Potential patients in dental care, including parents or caregivers making treatment decisions; excludes patients with…

Dental caries (study-defined binary; assessed by DMFT, number of dental caries, or dentist diagnosis) · Adults (≥18 years) · By confounder adjustment: not adjusted

Log diagnostic odds ratio · Imaging modality: Intraoral photographic images

detection of proximal caries · human primary or permanent teeth with dental caries lesions · Permanent dentition (all 3 included studies)

Amalgam: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration · Coverage: Not covering

Composite: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration · Continent: Africa

Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR Weighted Median

Fracture of forearm · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for DMFS

Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Medium HDI

Amalgam: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a… · Not applicable (single time-point survey, June to October 2023), Continent: Asia

Clinical and radiographic success · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible… · >=12 months

Radiographic hard-tissue (dentine) barrier formation · Mature permanent (molar) teeth with deep caries and symptoms indicative of irreversible pulpitis (spontaneous pain) · 1 year

detection of proximal caries · human primary or permanent teeth with dental caries lesions · permanent dentition

Sensitivity · Imaging modality: CBCT

Dental caries discrimination (area under the curve) · Children and adolescents (≤18 years) · Validation assessment; prediction horizon not reported, Yaxuan (2023)

Femur fracture · European GWAS participants · SVMR Weighted Median

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Composite: Preference for replacement over repair - Scenario 5: open margin · Continent: Asia

Dental caries severity (DMFT index, permanent dentition) · Children and adolescents under 18 years with HIV · Not specified (case-control), Case-control studies; DMFT index

Proximal caries detection: specificity · Extracted human teeth (in vitro); permanent teeth, proximal (approximal) surfaces · Overall (all studies permanent)

Composite: Preference for replacement over repair - Scenario 6: superficial discoloration · HDI: Medium

Composite: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration · HDI: Low

Tooth loss and dental symptoms (cracked teeth, toothache) associated with e-cigarette use · Yang et al. [31]

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Amalgam: Preference for replacement over repair - Scenario 6: corrosion · Continent: Asia

Femur fracture · European GWAS participants · SVMR Maximum Likelihood

Composite: Preference for replacement over repair - Scenario 3: secondary caries · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of… · Not applicable (single time-point survey, June to October 2023), Continent: Asia

Enamel/dental hard-tissue changes and e-liquid cariogenic properties (demineralization, colour change, pH, sugar content, metals) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few…

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · HDI: Low

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Risk of fragility fractures · General population (both sexes, all ages) · Long-term / lifetime fluoride exposure, Sensitivity (excluding high risk-of-bias studies): 1.8 mg/L vs null

Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR Weighted Median

Streptococcus mutans and Veillonella spp. levels · Young children with early childhood caries and caries-free controls

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Dental caries increment, DMFT/dmft (whole-tooth level) · Children in school or kindergarten settings (aged 3-14 years) · 3-4 years follow-up

Amalgam: Preference for replacement over repair - Scenario 3: secondary caries · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a… · Not applicable (single time-point survey, June to October 2023), Overall (all 21 countries pooled)

Delay of dental care during the COVID-19 pandemic · Potential patients in dental care, including parents or caregivers making treatment decisions; excludes patients with… · US patients at COVID-19 onset (Papautsky et al. convenience sample, n=2570)

Oral microbial community composition and diversity (other caries-associated taxa; alpha- and beta-diversity) · Systemically healthy individuals (children and adults, aged 40 months to 50 years) assessed for dental caries · Cross-sectional

Prevalence of early childhood caries · Children up to 71 months · 12-24 months

Lumbar spine and pelvis fracture · European GWAS participants · SVMR MR-Egger

Correlation of Veillonella spp. with acidogenic streptococci · Young children with early childhood caries and caries-free controls

Clinical and radiographic success rate · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure · Immediate restoration

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + biological ACAD