Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

124 questions · 126 findings · 91 reviews · Headline outcomes only

No studies found 12 · 9.5%GRADE not reported 6 · 4.8%Very low 36 · 28.6%Low 46 · 36.5%Moderate 18 · 14.3%High 8 · 6.3%

Certolizumab pegol 200 mg sc (with or without MTX) vs placebo (with or without MTX)

Withdrawals due to adverse events · patients with rheumatoid arthritis in adults

Certolizumab pegol 200 mg sc (with or without MTX) leads to higher withdrawals due to adverse events All doses of certolizumab pegol… compared with placebo (with or without MTX) (high certainty).

1 finding from 1 review

Paracetamol vs placebo

Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in withdrawals due to adverse events 24 weeks compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Stem Cell vs placebo or control

Withdrawals due to adverse events · Induction of Remission in Medically Refractory Crohn's Disease

It is very uncertain whether summary of findings table ‐ Stem Cell changes withdrawal due to adverse events compared with placebo or Control (very low certainty).

1 finding from 1 review

Antihypertensive drug therapy vs placebo or no treatment

Withdrawals due to adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes withdrawal due to adverse events compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs placebo

Withdrawals due to adverse events · people with surgically‐induced remission in Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in withdrawal due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review