Cochrane · systematic review · CD013070
Stem cell transplantation for induction of remission in medically refractory Crohn’s disease
El-Nakeep, S, Shawky, A, Abbas, SF, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Stem Cell compared to Placebo or Control for Induction of Remission in Medically Refractory Crohn?s Disease
Population: Induction of Remission in Medically Refractory Crohn's Disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical remission Summary of findings table ‐ Stem Cell vs Placebo or Control | RR 1.88 [0.8, 4.41] | 3 studies · 301 participants | Low Downgraded: risk of bias, inconsistency |
CDAI <150 at 24 weeks Summary of findings table ‐ Stem Cell vs Placebo or Control | RR 1.02 [0.67, 1.56] | 4 studies · 352 participants | Very low Downgraded: imprecision, inconsistency, publication bias |
Fistula Closure short‐term Summary of findings table ‐ Stem Cell vs Placebo or Control | RR 1.48 [1.12, 1.96] | 4 studies · 269 participants | Low Downgraded: risk of bias, imprecision |
Fistula closure in long‐term Summary of findings table ‐ Stem Cell vs Placebo or Control | RR 1.42 [1.09, 1.87] | 4 studies · 250 participants | Low Downgraded: risk of bias, imprecision |
Total Adverse Events Summary of findings table ‐ Stem Cell vs Placebo or Control | RR 0.99 [0.88, 1.13] | 4 studies · 293 participants | Very low Downgraded: risk of bias, inconsistency |
Serious Adverse Events Summary of findings table ‐ Stem Cell vs Placebo or Control | RR 1.22 [0.88, 1.67] | 7 studies · 433 participants | Low Downgraded: risk of bias |
Withdrawal due to adverse events Summary of findings table ‐ Stem Cell vs Placebo or Control | RR 0.78 [0.32, 1.89] | 3 studies · 272 participants | Very low Downgraded: imprecision, indirectness |