Cochrane · systematic review · CD003781
Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults
Stoniute, A, Madhuvrata, P, Still, M, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
IncontinenceAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anticholinergics compared to placebo for overactive bladder syndrome in adults
Population: adults with overactive bladder syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean change from baseline in condition‐specific quality of lifeScale from: ‐100 to 0 Anticholinergics vs placebo | MD 4.41 | 12 studies · 6804 participants | Low Downgraded: risk of bias |
Patient perception of cure or improvement Anticholinergics vs placebo | RR 1.38 [1.15, 1.66] | 9 studies · 8457 participants | Moderate Downgraded: risk of bias |
Mean number of urgency episodes per 24 hours Anticholinergics vs placebo | MD 0.85 | 23 studies · 16875 participants | Moderate Downgraded: risk of bias |
Adverse events: dry mouth Anticholinergics vs placebo | RR 3.5 [3.26, 3.75] | 66 studies · 38368 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Adverse events:urinary retention Anticholinergics vs placebo | RR 3.52 [2.04, 6.08] | 17 studies · 7862 participants | Low Downgraded: risk of bias |
Withdrawal due to adverse events Anticholinergics vs placebo | RR 1.37 [1.21, 1.56] | 61 studies · 36943 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Mean number of micturitions per 24 hours Anticholinergics vs placebo | MD 0.85 | 30 studies · 19395 participants | Moderate Downgraded: risk of bias |