Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

128 questions · 130 findings · 92 reviews

No studies found 12 · 9.2%GRADE not reported 10 · 7.7%Very low 36 · 27.7%Low 46 · 35.4%Moderate 18 · 13.8%High 8 · 6.2%

Diacerein vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Diacerein showed no clear difference in withdrawal due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Allopurinol vs placebo

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Pregabalin vs placebo at end of treatment

Withdrawals due to adverse events · patients with fibromyalgia

Pregabalin leads to higher withdrawal due to adverse events compared with placebo at end of treatment (high certainty).

1 finding from 1 review

Intermittent/cyclic etidronate 400 mg/day vs placebo

Withdrawals due to adverse events · postmenopausal women with a higher risk for fracturesa

It is very uncertain whether intermittent/cyclic etidronate 400 mg/day changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Infliximab 5–10 mg/kg vs placebo

Withdrawals due to adverse events · Patients with active Crohn's disease

The review found no eligible studies for this question.

2 findings from 1 review