Cochrane · systematic review · CD012954
Cannabis for the treatment of ulcerative colitis
Kafil, TS, Nguyen, TM, MacDonald, JK, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
8
No studies
6
Included studies
NR
No studies 6 · 42.9%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 35.7%Moderate 3 · 21.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Cannabidiol compared to placebo for the treatment of ulcerative colitis
Population: participants with active ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical remission at 10 weeks Cannabidiol vs placebo | RR 0.94 [0.39, 2.25] | 1 study · 60 participants | Low Downgraded: imprecision |
Clinical response at 10 weeks Cannabidiol vs placebo | RR 1.37 [0.59, 3.21] | 1 study · 60 participants | Low Downgraded: imprecision |
CRP at 10 weeks Cannabidiol vs placebo | no estimate extracted | 1 study · 59 participants | Moderate Downgraded: imprecision |
Quality of life Inflammatory Bowel Disease Questionnaire (IBDQ) at 10 weeks Cannabidiol vs placebo | no estimate extracted | 1 study · 53 participants | Moderate Downgraded: imprecision |
Adverse events Cannabidiol vs placebo | RR 1.28 [1.05, 1.56] | 1 study · 60 participants | Moderate Downgraded: imprecision |
Serious adverse events Cannabidiol vs placebo | RR 0.15 [0.01, 2.83] | 1 study · 60 participants | Low Downgraded: imprecision |
Withdrawal due to adverse event Cannabidiol vs placebo | RR 2.14 [0.83, 5.51] | 1 study · 60 participants | Low Downgraded: imprecision |
Cannabis cigarettes compared to placebo for the treatment of ulcerative colitis
Population: participants with active ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical remission Cannabis cigarettes vs placebo | no estimate extracted | NR | No studies |
Clinical response Cannabis cigarettes vs placebo | no estimate extracted | NR | No studies |
CRP at 8 weeks Cannabis cigarettes vs placebo | no estimate extracted | 1 study · 28 participants | Low Downgraded: imprecision |
Quality of life Inflammatory Bowel Disease Questionnaire (IBDQ) Cannabis cigarettes vs placebo | no estimate extracted | NR | No studies |
Adverse events Cannabis cigarettes vs placebo | no estimate extracted | NR | No studies |
Serious adverse events Cannabis cigarettes vs placebo | no estimate extracted | NR | No studies |
Withdrawal due to adverse events Cannabis cigarettes vs placebo | no estimate extracted | NR | No studies |