Cochrane · systematic review · CD012849
Probiotics for management of functional abdominal pain disorders in children
Gordon, M, Wallace, C, Sinopoulou, V, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 11 · 78.6%Low 3 · 21.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Probiotic compared to placebo for management of functional abdominal pain disorders in children
Population: children (4 to 18 years) with functional abdominal pain disorders
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment success (at study end, as reported by study authors) Probiotic vs placebo | RR 1.57 [1.05, 2.36] | 6 studies · 554 participants | Low Downgraded: risk of bias, inconsistency |
Complete resolution of pain (at study end, as reported by study authors) Probiotic vs placebo | RR 1.55 [0.94, 2.56] | 6 studies · 460 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Severity of pain (at study end, using the Faces Pain Scale) Probiotic vs placebo | no estimate extracted | 7 studies · 665 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Frequency of pain (at study end, episodes per week) Probiotic vs placebo | no estimate extracted | 6 studies · 605 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Withdrawals due to adverse events Probiotic vs placebo | RR 1 [0.07, 15.12] | 8 studies · 544 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events Probiotic vs placebo | no estimate extracted | 9 studies · 685 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events (any) Probiotic vs placebo | RR 1 [0.07, 15.12] | 7 studies · 489 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Synbiotic compared to placebo for management of functional abdominal pain disorders in children
Population: children (4 to 18 years) with functional abdominal pain disorders
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment success (at study end, as reported by study authors) Synbiotic vs placebo | RR 1.34 [1.03, 1.74] | 4 studies · 310 participants | Low Downgraded: imprecision |
Complete resolution of pain (at study end, as reported by study authors) Synbiotic vs placebo | RR 1.65 [0.97, 2.81] | 2 studies · 131 participants | Low Downgraded: imprecision |
Severity of pain (at study end, using the Faces Pain Scale) Synbiotic vs placebo | no estimate extracted | 4 studies · 319 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Frequency of pain (at study end, episodes per week) Synbiotic vs placebo | no estimate extracted | 1 study · 80 participants | Very low Downgraded: imprecision |
Withdrawals due to adverse events Synbiotic vs placebo | RR 4.58 [0.8, 26.19] | 4 studies · 302 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events Synbiotic vs placebo | no estimate extracted | 4 studies · 302 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events (any) Synbiotic vs placebo | RR 2.88 [0.32, 25.92] | 3 studies · 189 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |