Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

45 questions · 45 findings · 27 reviews

No studies found 16 · 35.6%GRADE not reported 0 · 0%Very low 14 · 31.1%Low 8 · 17.8%Moderate 6 · 13.3%High 1 · 2.2%

Higher BP target (< 150‐160/95‐105 mmHg) vs lower BP target (< 140/90 mmHg)

Serious adverse events: cardiovascular events · older adults with primary hypertension

Higher BP target (< 150‐160/95‐105 mmHg) showed no clear difference in cardiovascular serious adverse events compared with lower BP target (< 140/90 mmHg) (low certainty).

1 finding from 1 review

First‐line thiazides vs calcium channel blockers

Total serious adverse events Duration: 1.75 to 3 years · patients with hypertension

First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).

1 finding from 1 review

Intervention not reported

Serious Adverse Events (Participants with one or more event) · Adults (>18 years) with pulmonary hypertension of varied aetiology (PAH, CTEPH and left heart disease)

It is very uncertain whether the intervention changes serious Adverse Events (Participants with one or more event) (very low certainty).

1 finding from 1 review