Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 10 reviews · Neonatal

No studies found 7 · 38.9%GRADE not reported 0 · 0%Very low 7 · 38.9%Low 3 · 16.7%Moderate 0 · 0%High 1 · 5.6%

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Retinopathy of prematurity · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes retinopathy of prematurity, any stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (stage ≥ 3) · preterm infants with low birth weight

The intervention showed no clear difference in retinopathy of prematurity (stage ≥ 3) (high certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Retinopathy of prematurity, > stage 3 · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

It is very uncertain whether supine midline head position changes retinopathy of prematurity, > stage 3 compared with any other supine head position (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

It is very uncertain whether all alternative LE changes retinopathy of prematurity (≥ stage 3) compared with S‐LE (very low certainty).

1 finding from 1 review

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · preterm infants

Lower showed no clear difference in severe retinopathy of prematurity (≥ stage 3) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

1 finding from 1 review

Cerebral NIRS oximetry vs no cerebral NIRS oximetry

Retinopathy of prematurity, any or severe (stage ≥ III) · patients with preventing morbidity and mortality in very preterm infants

It is very uncertain whether cerebral NIRS oximetry changes retinopathy of prematurity, any or severe (stage ≥ III) compared with no cerebral NIRS oximetry (very low certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (stage ≥ 3) during initial hospital stay · preterm infants with low birth weight

It is very uncertain whether the intervention changes retinopathy of prematurity (stage ≥ 3) during initial hospital stay (very low certainty).

1 finding from 1 review

Superoxide dismutase (SOD) vs placebo

Severe retinopathy of prematurity (stage II or greater)№ of participants: 244(1 RCT) · preterm infants at risk for bronchopulmonary dysplasia

It is very uncertain whether superoxide dismutase (SOD) changes severe retinopathy of prematurity (stage II or greater)№ of… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (all stages or stage not reported) during initial hospital stay · preterm infants with low birth weight

It is very uncertain whether the intervention changes retinopathy of prematurity (all stages or stage not reported) during… (very low certainty).

1 finding from 1 review