What do systematic reviews say?

Hypertonic saline vs Normal saline

• Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Moderate

Sclerotherapy (hypertonic saline) vs sclerotherapy (any sclerosant)

The review found no eligible studies for this question.

• Treatment for telangiectasias and reticular veins 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

• Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Injectional nicardipine vs Normal saline

The review found no eligible studies for this question.

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Injectional betamethasone vs Normal saline

The review found no eligible studies for this question.

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Injectional verapamil vs saline (short‐term)

The review found no eligible studies for this question.

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Injectional interferon alpha‐2B vs Normal saline

The review found no eligible studies for this question.

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

The review found no eligible studies for this question.

• Hyperimmune immunoglobulin for people with COVID‐19 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hyperimmune immunoglobulin from human plasma vs saline placebo

The review found no eligible studies for this question.

• Hyperimmune immunoglobulin for people with COVID‐19 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes

  High-dose melphalan-based treatment prior to HSCT (haematological cancers)
  Summary of findings 2 (melphalan/HSCT): Quality of life - '1 study assessed this outcome but the data are currently unavailable as the study report and analysis have not yet been completed' (Toro 2013; measured with…
  1 study
  GRADE not reported
• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes

  Fluorouracil (5FU) treatment for solid cancers
  Summary of findings for the main comparison (5FU solid cancers): Quality of life - 'No studies assessed this outcome'.
  0 studies
  No studies found

Local corticosteroid injection (LCI) vs saline no treatment or placebo

• Local corticosteroid injection versus placebo for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 111 participants
  Moderate

Hydrogel dressings vs saline gauze

The review found no eligible studies for this question.

• Hydrogel dressings for venous leg ulcers 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Propyl betaine and polihexanide vs Normal saline

The review found no eligible studies for this question.

• Wound cleansing for treating venous leg ulcers 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Polyhexamethylene biguanide (PHMB) vs Normal saline

The review found no eligible studies for this question.

• Wound cleansing for treating venous leg ulcers 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Gemcitabine vs Normal saline

The review found no eligible studies for this question.

• Intravesical gemcitabine for non‐muscle invasive bladder cancer 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical phenytoin vs saline dressing

The review found no eligible studies for this question.

• Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dornase alfa vs hypertonic saline

Dornase alfa showed no clear difference in mean relative percentage in quality of life score at 3 months compared with hypertonic saline (low certainty).

• Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
  MD 0.03
  431 participants
  Low

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 5.25% vs Normal saline

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found