What do systematic reviews say?

Concomitant (concurrent) chemoradiotherapy vs chemoradiotherapy plus surgery

• Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 165 participants
  Very low

Radiotherapy vs control

• Radiotherapy for neovascular age‐related macular degeneration 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Radiotherapy (morning) vs Afternoon radiotherapy

• Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
  Bjarnason 2009: no statistically significant difference in quality of life scores (data not reported). Morning radiotherapy was associated with significantly less weight loss after 5 months.
  1 study · 216 participants
  GRADE not reported

Laminectomy plus radiotherapy vs radiotherapy

The review found no eligible studies for this question.

• Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Hypofractionated radiotherapy vs radiotherapy

The review found no eligible studies for this question.

• Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Hyperfractionated radiotherapy vs radiotherapy

The review found no eligible studies for this question.

• Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Radiotherapy vs botulinum toxin

The review found no eligible studies for this question.

• Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

The review found no eligible studies for this question.

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

The review found no eligible studies for this question.

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

The review found no eligible studies for this question.

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 361 participants
  GRADE not reported

Single‐fraction radiotherapy (8 Gy) vs short‐course radiotherapy (16 Gy

The review found no eligible studies for this question.

• Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Decompressive surgery plus radiotherapy vs radiotherapy

The review found no eligible studies for this question.

• Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Preoperative radiotherapy vs surgery

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 3211 participants
  Low

Daily conventionally fractionated radiotherapy vs supportive care

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 81 participants
  GRADE not reported

Split‐course radiotherapy (8 fractions, 30 Gy) vs short‐course radiotherapy (16 Gy

The review found no eligible studies for this question.

• Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Radiotherapy combined with anti‐VEGF vs anti‐VEGF alone

The review found no eligible studies for this question.

• Radiotherapy for neovascular age‐related macular degeneration 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

EGFR monoclonal antibody (cetuximab or nimotuzumab) plus standard therapy (radiotherapy or chemoradiotherapy) vs Standard therapy alone (radiotherapy or chemoradiotherapy)

• Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy 2015 · Cochrane All outcomes

  24 to 70 months
  Only one study (Bonner 2006, 424 participants) comprehensively assessed quality of life using EORTC QLQ-C30 (v3.0) and QLQ-H&N35; no statistically significant difference between groups for global health status or any…
  1 study · 424 participants
  GRADE not reported