Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

249 questions · 267 findings · 154 reviews

No studies found 32 · 12%GRADE not reported 32 · 12%Very low 72 · 27%Low 71 · 26.6%Moderate 54 · 20.2%High 6 · 2.2%

Intervention not reported

Quality of Life SF‐36 Mental Summary score (scale 0 to 100, higher score indicates better quality of life) · adults with intermittent claudication
1 finding from 1 review

Intervention not reported

HRQoL Using EQ‐5D (range 0 to 1) and HOOS (range 0 to 100). A higher score indicates better quality of life. · adults following hip fracture surgery

It is very uncertain whether the intervention changes HRQoL Using EQ‐5D (range 0 to 1) and HOOS (range 0 to 100). A higher… (very low certainty).

1 finding from 1 review

Whole‐facility changes: Home‐like models vs traditional environment

Health‐related quality of life Dementia‐specific quality of life measure (QUALIDEM) (higher scores = better) · older adults living in long‐term residential care including, but not limited to, dementia‐specific care settings
1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Mean change in VAS (higher scores suggest greater disease activity and worse quality of life) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in mean change in VAS (higher scores suggest greater disease activity… compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 26‐week taper

Mean change in VAS (higher scores suggest greater disease activity and worse quality of life) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in mean change in VAS (higher scores suggest greater disease activity… compared with placebo + 26‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab every other week vs placebo + 52‐week taper

Mean change in VAS (higher scores suggest greater disease activity and worse quality of life) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every other week showed no clear difference in mean change in VAS (higher scores suggest greater disease activity… compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab every other week vs placebo + 26‐week taper

Mean change in VAS (higher scores suggest greater disease activity and worse quality of life) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every other week showed no clear difference in mean change in VAS (higher scores suggest greater disease activity… compared with placebo + 26‐week taper (moderate certainty).

1 finding from 1 review