What do systematic reviews say?

CBT vs anxiety management

• Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Low

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 212 participants
  Moderate

Continuous chest compression plus ventilation vs interrupted chest compression plus artificial ventilation

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Aclidinium bromide vs tiotropium

• Aclidinium bromide for stable chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Telerehabilitation vs centre‐based (outpatient) pulmonary rehabilitation

Telerehabilitation showed no clear difference in quality of life ‐ CAT compared with centre‐based (outpatient) pulmonary rehabilitation (moderate certainty).

• Telerehabilitation for chronic respiratory disease 2021 · Cochrane Headline outcomes only
  MD 1.37
  2 studies · 224 participants
  Moderate

Telerehabilitation vs centre‐based (outpatient) pulmonary rehabilitation

Telerehabilitation showed no clear difference in quality of life ‐ SGRQ compared with centre‐based (outpatient) pulmonary rehabilitation (low certainty).

• Telerehabilitation for chronic respiratory disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 274 participants
  Low

Umeclidinium bromide vs placebo

Umeclidinium bromide probably leads to higher quality of life: number of participants with ≥ 4 units improvement… compared with placebo (moderate certainty).

• Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD) 2017 · Cochrane Headline outcomes only
  OR 1.45 [1.16, 1.82]
  3 studies · 1397 participants
  Moderate

Indacaterol vs long‐acting beta2‐agonist alone

Indacaterol showed no clear difference in number of participants with a clinically significant improvement in… compared with twice‐daily long‐acting beta2‐agonists (moderate certainty).

• Indacaterol, a once‐daily beta₂‐agonist, versus twice‐daily beta₂‐agonists or placebo for chronic obstructive… 2015 · Cochrane Headline outcomes only
  OR 1.07 [0.87, 1.32]
  2 studies · 1520 participants
  Moderate

Macrolide+tetracycline vs macrolides

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 187 participants
  Very low

Aclidinium bromide vs placebo

Aclidinium bromide leads to higher quality of life Number of patients who achieved at least 4 units… compared with placebo (high certainty).

• Aclidinium bromide for stable chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
  OR 1.49 [1.31, 1.7]
  7 studies · 4420 participants
  High

Long‐acting beta2‐agonists vs placebo

Long‐acting beta2‐agonists showed no clear difference in quality of life1 St George's Respiratory Questionnaire (SGRQ); lower… compared with placebo (moderate certainty).

• Long‐acting beta₂‐agonists for chronic obstructive pulmonary disease 2013 · Cochrane Headline outcomes only
  no estimate extracted
  17 studies · 11397 participants
  Moderate

Action plan vs usual care

• Action plans with brief patient education for exacerbations in chronic obstructive pulmonary disease 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1009 participants
  Moderate

Intervention not reported

• Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 267 participants
  Low

Fixed‐dose combination aclidinium/formoterol vs placebo

Fixed‐dose combination aclidinium/formoterol leads to higher quality of life: number of participants with clinically significant… compared with placebo (high certainty).

• Combined aclidinium bromide and long‐acting beta2‐agonist for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
  OR 1.72 [1.39, 2.13]
  2 studies · 1823 participants
  High

Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation

• Catheter‐directed therapies for the treatment of high risk (massive) and intermediate risk (submassive) acute… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  GRADE not reported

Non‐invasive ventilation during exercise training vs exercise training alone or exercise training with sham non‐invasive ventilation

• Non‐invasive ventilation during exercise training for people with chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 48 participants
  Moderate

Quinolone vs macrolides

The review found no eligible studies for this question.

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Macrolides vs tetracycline

The review found no eligible studies for this question.

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Quinolone vs tetracycline

The review found no eligible studies for this question.

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found