What do systematic reviews say?

Summary of findings table ‐ Psychosocial interventions intended primarily to reduce antipsychotic use vs (Optimised) usual care

• Psychosocial interventions for reducing antipsychotic medication in care home residents 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2 participants
  Moderate

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  6 months
  QoL measured with the Duke Health Profile; only within-group comparisons were provided; no score values, so a between-group analysis was not possible.
  1 study
  GRADE not reported

Complete cure and adverse events for terbinafine vs placebo

The review found no eligible studies for this question.

• Oral antifungal medication for toenail onychomycosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Azoles vs placebo

The review found no eligible studies for this question.

• Oral antifungal medication for toenail onychomycosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Griseofulvin vs azole

The review found no eligible studies for this question.

• Oral antifungal medication for toenail onychomycosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Griseofulvin vs terbinafine

The review found no eligible studies for this question.

• Oral antifungal medication for toenail onychomycosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Combination terbinafine plus azole vs terbinafine

The review found no eligible studies for this question.

• Oral antifungal medication for toenail onychomycosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Azoles vs terbinafine

The review found no eligible studies for this question.

• Oral antifungal medication for toenail onychomycosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation vs continuation of antipsychotic medication

• Withdrawal versus continuation of long‐term antipsychotic drug use for behavioural and psychological symptoms in older… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 119 participants
  Low

Laser trabeculoplasty vs medication

Laser trabeculoplasty showed no clear difference in quality of life measures compared with medication (moderate certainty).

• Laser trabeculoplasty for open‐angle glaucoma and ocular hypertension 2022 · Cochrane Headline outcomes only
  MD 0.28
  Studies not reported
  Moderate

Summary of findings: multimedia education vs control multimedia

• Multimedia educational interventions for consumers about prescribed and over‐the‐counter medications 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 269 participants
  Moderate

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Commercial mouthcare system (Biotene Oral Balance / Xerostom) vs Usual care or CMC-based control

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Ship 2007 reported xerostomia-related quality of life; no usable comparative data.
  1 study
  GRADE not reported

Commercial mouthcare system (Biotene Oral Balance / Xerostom) vs Bioxtra mouthcare system

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  No difference between systems for overall xerostomia-related quality of life (15-item survey). Bioxtra rated better for taste; no difference for mouth 'feel'. Trial likely underpowered.
  1 study · 20 participants
  GRADE not reported

Tricyclic antidepressants vs another medication

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs a combination of medications

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hydrus microstent vs iStent trabecular micro‐bypass stent

The review found no eligible studies for this question.

• Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cataract surgery with Hydrus microstent vs cataract surgery alone

The review found no eligible studies for this question.

• Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Radioiodine therapy versus antithyroid medications for Graves' disease 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 425 participants
  GRADE not reported