Findings

What do systematic reviews say?

71 questions · 71 findings · 35 reviews

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No studies found 37 · 52.1%GRADE not reported 13 · 18.3%Very low 11 · 15.5%Low 6 · 8.5%Moderate 4 · 5.6%High 0 · 0%

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT

Health‐related quality of life (HRQoL) · people with single or solitary brain metastasis

1 finding from 1 review

Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Health‐related quality of life (HRQoL) · people with single or solitary brain metastasis

1 finding from 1 review

Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Very low

Summary of findings table ‐ Postmastectomy radiotherapy (PMRT) vs no PMRT

QoL · women with breast cancer and one to three positive lymph nodes

1 finding from 1 review

Post‐mastectomy radiotherapy for women with early breast cancer and one to three positive lymph nodes 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Health‐related quality of life · participants with unresectable hepatocellular carcinoma

The review found no eligible studies for this question.

1 finding from 1 review

External beam radiotherapy for unresectable hepatocellular carcinoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hysterectomy (radical) with neoadjuvant chemotherapy vs chemoradiotherapy alone

Quality of life · women with locally advanced cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hysterectomy (simple or radical) with neoadjuvant chemotherapy vs Radiotherapy alone

Quality of life · women with locally advanced cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo

Quality of life · participants with cancer treated with radiotherapy (with or without chemotherapy)

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 72 participants
Low

Edaravone plus corticosteroids vs corticosteroids

Quality of life · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: bevacizumab vs placebo

Quality of life · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amifostine vs no treatment/placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine showed no clear difference in quality of life compared with no treatment/placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
End of RT; up to 3 months postRT
MD 0.52 [-0.02, 1.06]
1 study · 233 participants
GRADE not reported

Antiseptic mouthrinse vs placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No quality of life data were reported.
0 studies
No studies found

Bethanechol vs placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on either quality of life or other oral related symptoms were reported.
0 studies
No studies found

Chinese medicine vs no treatment/placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
End of intervention to 3 months postRT
Insufficient evidence to determine any effect on quality of life (Lin 2014; Analysis 6.5)
1 study
GRADE not reported

Amifostine (intravenous) vs Amifostine (subcutaneous)

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on either quality of life or other oral related symptoms were reported.
0 studies
No studies found

Dexamethasone vs placebo

Quality of life · participants with advanced cancer who have nausea and vomiting not related to chemotherapy, radiotherapy, or surgery

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy,… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Venalot Depot (coumarin plus troxerutin) vs placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on either quality of life or other oral related symptoms were reported.
0 studies
No studies found

Amifostine 200 mg/m2 three times weekly vs Amifostine 200 mg/m2 five times weekly

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
End of RT and 6, 12, 18, 24 months postRT
No significant differences between the three treatment arms (Jellema 2006)
1 study
GRADE not reported

Bethanechol vs Artificial saliva

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on either quality of life or other oral related symptoms were reported.
0 studies
No studies found

Intervention not reported

Quality of life ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hyperbaric oxygen vs air breathing

Quality of life ‐ not reported · People undergoing radiotherapy for uterine cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found