Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

132 questions · 134 findings · 60 reviews

No studies found 50 · 37.3%GRADE not reported 6 · 4.5%Very low 34 · 25.4%Low 17 · 12.7%Moderate 20 · 14.9%High 7 · 5.2%

Silver diamine fluoride (SDF) vs placebo

Oral health-related quality of life · Children with dental caries

SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded).

1 finding from 1 review

Zinc vs placebo

QoL of participants living with SCD and their caregivers · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Serenoa repens vs placebo or no intervention

QoL · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens showed no clear difference in quality of lifeMeasured by IPSS‐QoL score (range 0 to 6) compared with placebo or no intervention (high certainty).

1 finding from 1 review

Silver diamine fluoride (SDF, including SDF + fluoride varnish) vs Other standard-of-care caries treatments pooled (placebo, ART, or ART + fluoride varnish)

Oral health-related quality of life · Children with dental caries

SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded).

1 finding from 1 review