Cochrane · systematic review · CD010858
Vitamin D supplementation for sickle cell disease
Soe, HH, Abas, ABL, Than, NN, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
9
No studies
5
Included studies
NR
No studies 5 · 35.7%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 35.7%Moderate 4 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsVitamin D versus placebo for sickle cell disease
Population: people with sickle cell disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum 25(OH)D level (change from baseline) Vitamin D vs placebo | no estimate extracted | 1 study · 37 participants | Moderate |
Total body BMD measured by DEXA (% change from baseline) Vitamin D vs placebo | no estimate extracted | NR | No studies |
Adverse events Vitamin D vs placebo | RR 3.16 [0.14, 72.84] | 1 study · 37 participants | Low Downgraded: imprecision |
Frequency of pain (change from baseline) Vitamin D vs placebo | no estimate extracted | 1 study · 37 participants | Low Downgraded: imprecision |
Acute chest syndrome Vitamin D vs placebo | no estimate extracted | NR | No studies |
Respiratory infections Vitamin D vs placebo | no estimate extracted | NR | No studies |
HRQoL score (physical functioning) (change from baseline) Vitamin D vs placebo | no estimate extracted | 1 study · 37 participants | Low Downgraded: imprecision |
Vitamin D 100,000 IU/month versus 12,000 IU/month for sickle cell disease
Population: people with sickle cell disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum 25‐hydroxyvitamin D (25(OH)D) level (change from baseline) (ng/mL) Vitamin D 100,000 IU/month vs 12,000 IU/month | no estimate extracted | 1 study · 57 participants | Low Downgraded: imprecision |
Total body BMD measured by DEXA (% change from baseline) Vitamin D 100,000 IU/month vs 12,000 IU/month | no estimate extracted | NR | No studies |
Adverse events Vitamin D 100,000 IU/month vs 12,000 IU/month | no estimate extracted | 1 study · 62 participants | Low Downgraded: imprecision |
Presence of pain Vitamin D 100,000 IU/month vs 12,000 IU/month | RR 1 [0.62, 1.62] | 1 study · 62 participants | Moderate |
Acute chest syndrome Vitamin D 100,000 IU/month vs 12,000 IU/month | no estimate extracted | 1 study · 62 participants | Moderate |
Respiratory infections Vitamin D 100,000 IU/month vs 12,000 IU/month | no estimate extracted | 1 study · 62 participants | Moderate |
HRQoL (using a validated scale) Vitamin D 100,000 IU/month vs 12,000 IU/month | no estimate extracted | NR | No studies |