Cochrane · systematic review · CD012949
Probiotics for people with cystic fibrosis
Coffey, MJ, Garg, M, Homaira, N, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Probiotics compared to placebo for children and adults with CF
Population: children and adults with CF
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of pulmonary exacerbations Probiotics vs placebo | no estimate extracted | 4 studies · 225 participants | Low Downgraded: risk of bias, indirectness |
Faecal calprotectin Probiotics vs placebo | no estimate extracted | 4 studies · 177 participants | Low Downgraded: risk of bias, indirectness |
Adverse events (serious adverse reaction and adverse reaction) Probiotics vs placebo | RR 3 [0.49, 18.46] | 5 studies · 310 participants | Low Downgraded: risk of bias, indirectness |
Weight (z score) Probiotics vs placebo | no estimate extracted | 2 studies · 91 participants | Low Downgraded: risk of bias, indirectness |
Lung function (FEV1 % predicted) Probiotics vs placebo | no estimate extracted | 5 studies · 284 participants | Low Downgraded: risk of bias, indirectness |
Hospitalisations (all causes) Probiotics vs placebo | no estimate extracted | 2 studies · 115 participants | Low Downgraded: risk of bias, indirectness |
HRQoL (PedsQLTM 4.0 SF 15 (Scale from: 0 to 100)) Probiotics vs placebo | no estimate extracted | 1 study · 37 participants | Low Downgraded: risk of bias, indirectness |