Modified natural cycle FET (HCG trigger) vs HT FET
Multiple pregnancy rate · subfertile women
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
14 questions · 14 findings · 7 reviews · Headline outcomes only
No studies found 4 · 28.6%GRADE not reported 0 · 0%Very low 5 · 35.7%Low 4 · 28.6%Moderate 1 · 7.1%High 0 · 0%
Modified natural cycle FET (HCG trigger) vs HT + GnRHa FET
Multiple pregnancy rate · subfertile women
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
HT FET vs HT + GnRHa FET
Multiple pregnancy rate · women with primary or secondary subfertility
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
HMG FET vs clomiphene + HMG FET
Multiple pregnancy rate · subfertile women
It is very uncertain whether HMG FET changes multiple pregnancy rate per woman compared with clomiphene + HMG FET (very low certainty).
1 finding from 1 review
- OR 1.41 [0.31, 6.48]1 study · 209 participantsVery low
Natural cycle FET vs HT FET
Multiple pregnancy rate · subfertile women
It is very uncertain whether natural cycle FET changes multiple pregnancy rate per woman compared with HT FET (very low certainty).
1 finding from 1 review
- OR 2.48 [0.09, 68.14]1 study · 21 participantsVery low
Natural cycle FET vs HT + GnRHa FET
Multiple pregnancy rate · subfertile women
Natural cycle FET showed no clear difference in multiple pregnancy rate per woman compared with HT plus GnRHa suppression FET (low certainty).
1 finding from 1 review
- OR 0.58 [0.13, 2.5]1 study · 159 participantsLow
Day 3 vs Day 2 embryo transfer following IVF or ICSI
Multiple pregnancy rate · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection
Day 3 showed no clear difference in multiple pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).
1 finding from 1 review
- Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes onlyRR 1.12 [0.86, 1.44]8 studies · 1837 participantsModerate
Ultrasound‐guided transvaginal ovarian needle drilling with gonadotropin (Gn) vs Gn
Multiple pregnancy rate · clomiphene‐resistant polycystic ovarian syndrome in subfertile women
It is very uncertain whether ultrasound‐guided transvaginal ovarian needle drilling with… changes multiple pregnancy rate (per woman) compared with gn (very low certainty).
1 finding from 1 review
- Ultrasound-guided transvaginal ovarian needle drilling for clomiphene-resistant polycystic ovarian syndrome in… 2019 · Cochrane Headline outcomes onlyOR 1.25 [0.27, 5.77]2 studies · 155 participantsVery low
Metformin vs placebo co‐treatment
Multiple pregnancy rate · subfertile women with polycystic ovary syndrome
Metformin showed no clear difference in multiple pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
- Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes onlyOR 0.55 [0.15, 1.95]4 studies · 232 participantsLow
Glucocorticoid supplementation vs placebo
Multiple pregnancy rate · Women undergoing IVF/ICSI cycles
It is very uncertain whether glucocorticoid supplementation changes multiple pregnancy rate per woman/couple compared with placebo (very low certainty).
1 finding from 1 review
- Glucocorticoid supplementation during ovarian stimulation for IVF or ICSI 2017 · Cochrane Headline outcomes onlyOR 3.32 [0.12, 91.6]1 study · 20 participantsVery low
IVF vs IUI + ovarian stimulation with gonadotropins or CC
Multiple pregnancy rate · women with unexplained subfertility
IVF showed no clear difference in multiple pregnancy rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (low certainty).
1 finding from 1 review
- OR 0.82 [0.38, 1.77]3 studies · 731 participantsLow
IVF vs expectant management
Multiple pregnancy rate · women with unexplained subfertility
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
IVF vs unstimulated IUI
Multiple pregnancy rate · women with unexplained subfertility
It is very uncertain whether IVF changes multiple pregnancy rate per woman randomised compared with unstimulated IUI (very low certainty).
1 finding from 1 review
- OR 1.03 [0.04, 27.29]1 study · 43 participantsVery low
Assisted hatching vs no assisted hatching
Multiple pregnancy rate · women undergoing assisted reproduction
Assisted hatching may leads to higher multiple pregnancy rate per woman randomised compared with no assisted hatching (low certainty).
1 finding from 1 review
- Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes onlyOR 1.38 [1.13, 1.68]18 studies · 4308 participantsLow