Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 12 reviews

No studies found 4 · 16.7%GRADE not reported 0 · 0%Very low 6 · 25%Low 5 · 20.8%Moderate 9 · 37.5%High 0 · 0%

Human recombinant activated protein C vs placebo

In‐hospital mortality (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in in‐hospital mortality (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

28‐Day all‐cause mortality (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in 28‐Day all‐cause mortality (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

The introduction of nursing assistive personnel (NAP) to the hospital workforce vs usual staffing

Patient mortality · patients admitted to a cardiovascular surgery/urology/ophthalmology unit, a kidney transplant/plastic surgery unit, an oncology unit, or…

The review found no eligible studies for this question.

1 finding from 1 review

Geriatrician‐led inpatient management vs orthopaedic‐led inpatient management

Mortality at 12 months · adults with dementia following hip fracture surgery

It is very uncertain whether geriatrician‐led inpatient management changes mortality at 12 months compared with orthopaedic‐led inpatient management (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality within the longest · surgical patients with need for abdominal, caesarean section, orthopaedic or breast surgery

The intervention showed no clear difference in mortality within the longest (low certainty).

1 finding from 1 review

Intervention not reported

Mortality within the longest · surgical patients with need for abdominal, caesarean section, orthopaedic or breast surgery

It is very uncertain whether the intervention changes mortality within the longest (very low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Mortality within the longest · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (at longest compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

All‐cause mortality (up to 30 days) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (up to 30 days) compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review