Cochrane · systematic review · CD011312
Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease
Hummel, J, Rücker, G, Stiller, B · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsProphylactic levosimendan compared to standard treatment in children having undergone heart surgery
Population: paediatric patients following heart surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Prophylactic levosimendan vs standard treatment | RR 0.47 [0.12, 1.82] | 3 studies · 123 participants | Low Downgraded: imprecision |
Low cardiac output syndrome (LCOS) Prophylactic levosimendan vs standard treatment | RR 0.64 [0.39, 1.04] | 2 studies · 83 participants | Low Downgraded: imprecision |
Length of intensive care unit stay (Length of ICU stay) Prophylactic levosimendan vs standard treatment | no estimate extracted | 4 studies · 188 participants | Low Downgraded: imprecision |
Length of hospital stay Prophylactic levosimendan vs standard treatment | no estimate extracted | 2 studies · 75 participants | Low Downgraded: imprecision |
Duration of mechanical ventilation Prophylactic levosimendan vs standard treatment | no estimate extracted | 5 studies · 208 participants | Low Downgraded: imprecision |
Mechanical circulatory support or cardiac transplantation Prophylactic levosimendan vs standard treatment | RR 1.49 [0.19, 11.37] | 2 studies · 60 participants | Low Downgraded: imprecision |