What do systematic reviews say?

One intervention vs no intervention

One intervention showed no clear difference in perinatal mortality compared with no intervention (moderate certainty).

• Health system and community level interventions for improving antenatal care coverage and health outcomes 2015 · Cochrane Headline outcomes only
  OR 0.96 [0.89, 1.03]
  15 studies · 189164 participants
  Moderate

Combination of interventions vs no intervention

• Health system and community level interventions for improving antenatal care coverage and health outcomes 2015 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 39130 participants
  Moderate

Interventionist care vs expectant care

Interventionist care showed no clear difference in perinatal mortality or perinatal death compared with expectant (delayed delivery) care (low certainty).

• Interventionist versus expectant care for severe pre‐eclampsia between 24 and 34 weeks' gestation 2018 · Cochrane Headline outcomes only
  RR 1.11 [0.62, 1.99]
  3 studies · 343 participants
  Low

Dietary advice vs standard‐of‐care therapy

• Dietary advice interventions in pregnancy for preventing gestational diabetes mellitus 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 159 participants
  Very low

Dietary advice vs standard‐of‐care therapy

• Dietary advice interventions in pregnancy for preventing gestational diabetes mellitus 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Adverse event outcomes for dietary combined with physical activity interventions vs standard‐of‐care therapy

Combined diet and exercise interventions showed no clear difference in perinatal mortality compared with standard care (child) (low certainty).

• Combined diet and exercise interventions for preventing gestational diabetes mellitus 2017 · Cochrane Headline outcomes only
  RR 0.82 [0.42, 1.63]
  2 studies · 3757 participants
  Low

Adverse event outcomes for dietary combined with physical activity interventions vs standard‐of‐care therapy

• Combined diet and exercise interventions for preventing gestational diabetes mellitus 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Technique of BP measurement: CRADLE intervention vs usual care

The review found no eligible studies for this question.

• Setting and techniques for monitoring blood pressure during pregnancy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Balanced protein and energy supplementation vs no intervention or control intervention (control)

• Antenatal dietary education and supplementation to increase energy and protein intake 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Sildenafil vs IV nitroglycerin

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Sildenafil vs Placebo or no active treatment

Sildenafil citrate showed no clear difference in fetal mortality compared with placebo or no therapy (moderate certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.82 [0.6, 1.12]
  5 studies · 516 participants
  Moderate

Tadalafil vs Placebo or no active treatment

Tadalafil showed no clear difference in fetal mortality compared with placebo or no therapy (low certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.11 [0.01, 1.96]
  1 study · 87 participants
  Low

Nitroglycerin vs Placebo or no active treatment

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Sildenafil vs IV nitroglycerin

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Sildenafil vs Placebo or no active treatment

Sildenafil citrate showed no clear difference in neonatal mortality compared with placebo or no therapy (moderate certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 1.45 [0.9, 2.33]
  5 studies · 397 participants
  Moderate

Tadalafil vs Placebo or no active treatment

Tadalafil showed no clear difference in neonatal mortality compared with placebo or no therapy (low certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.89 [0.06, 13.7]
  1 study · 83 participants
  Low

Nitroglycerin vs Placebo or no active treatment

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Sildenafil vs Placebo or no active treatment

Sildenafil citrate showed no clear difference in all‐cause mortality compared with placebo or no therapy (moderate certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.8, 1.27]
  5 studies · 516 participants
  Moderate

Sildenafil vs IV nitroglycerin

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low