Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 15 findings · 6 reviews · Emergency and Critical Care

No studies found 4 · 26.7%GRADE not reported 0 · 0%Very low 2 · 13.3%Low 1 · 6.7%Moderate 5 · 33.3%High 3 · 20%

Intervention not reported

Mortality during critical care unit admission Measured using mortality rate in intervention and comparison groups During critical care admission · mechanically ventilated adults with need for aerosol bronchodilator therapy

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

Mortality within the longest · patients with vitamin K antagonist‐induced bleeding requiring acute intervention

It is very uncertain whether prothrombin complex concentrate changes overall mortality ‐ longest compared with any comparator (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · people suffering from high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

All‐cause mortality · people suffering from high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

IVIg vs placebo or no intervention

28‐Day all cause mortality (adult studies) · adult patients with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) probably leads to lower all‐cause mortality, adults, standard polyclonal IVIG compared with placebo or no intervention (moderate certainty).

5 findings from 1 review
Show 2 more findings

IVIg vs placebo or no intervention

All‐cause mortality, neonates, standard polyclonal IVIG · neonates with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in all‐cause mortality, neonates, standard polyclonal IVIG compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

IVIg vs placebo or no intervention

All‐cause mortality, neonates, IgM‐enriched polyclonal IVIG · neonates with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in all‐cause mortality, neonates, IgM‐enriched polyclonal IVIG compared with placebo or no intervention (low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

In‐hospital mortality within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Physical and cognitive therapy vs usual care

In‐hospital mortality at 30 days or at the longest · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or haemorrhagic shock who resided…

It is very uncertain whether physical and cognitive therapy changes in‐hospital mortality at 30 days or at the longest compared with standard care (very low certainty).

1 finding from 1 review