Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 9 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 1 · 9.1%Very low 3 · 27.3%Low 5 · 45.5%Moderate 2 · 18.2%High 0 · 0%

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

All‐cause mortality · prevention of sepsis and necrotizing enterocolitis in preterm infants

It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

Enteral zinc supplementation vs no zinc supplementation

All‐cause mortality (between start of intervention and end of · preterm infants

Enteral zinc supplementation may leads to lower all‐cause mortality (between start of intervention and end of compared with no zinc supplementation (low certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

All‐cause mortality (outcome collected through first event: death, hospital discharge, hospital transfer, or 120 days after birth) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in all‐cause mortality (outcome collected through first event: death,… compared with placebo (moderate certainty).

1 finding from 1 review

Slow vs faster rates of enteral feed advancement

Mortality before hospital discharge · very preterm or very low birth weight infants

Slow showed no clear difference in mortality before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Lactoferrin supplementation vs control

All‐cause Mortality№ of participants: 5510(11 RCTs) · prevention of sepsis and necrotizing enterocolitis in preterm infants

It is very uncertain whether lactoferrin supplementation changes all‐cause Mortality№ of participants: 5510(11 RCTs) compared with control (very low certainty).

1 finding from 1 review