Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

38 questions · 39 findings · 20 reviews

No studies found 1 · 2.6%GRADE not reported 1 · 2.6%Very low 20 · 51.3%Low 13 · 33.3%Moderate 4 · 10.3%High 0 · 0%

Enteral vs parenteral nutrition

All‐cause mortality · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral showed no clear difference in mortality compared with parenteral nutrition (low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

All‐cause mortality · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral showed no clear difference in mortality compared with enteral and parenteral nutrition (low certainty).

1 finding from 1 review

Postoperative feeding via nasojejunal tube vs postoperative parenteral nutrition (PN)

All‐cause mortality · adult patients after liver transplantation.

It is very uncertain whether postoperative enteral nutrition (Osmolite) via nasojejunal tube changes mortality compared with postoperative parenteral nutrition (PN) (very low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

All‐cause mortality · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in mortality compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition with supplemental parenteral nutrition (SPN) vs delayed enteral nutrition with SPN

Mortality (timing of outcome measurement unclear) · critically ill adult patients

It is very uncertain whether early enteral nutrition with supplemental parenteral nutrition (SPN) changes mortality (timing of outcome measurement unclear) compared with delayed enteral nutrition with SPN (very low certainty).

1 finding from 1 review

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

All‐cause mortality · prevention of sepsis and necrotizing enterocolitis in preterm infants

It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

Enteral zinc supplementation vs no zinc supplementation

All‐cause mortality (between start of intervention and end of · preterm infants

Enteral zinc supplementation may leads to lower all‐cause mortality (between start of intervention and end of compared with no zinc supplementation (low certainty).

1 finding from 1 review

Standard parenteral nutrition vs standard isotonic intravenous glucose solution

Mortality [within first 10 weeks after liver transplantation] · adult patients after liver transplantation.

Standard parenteral nutrition may leads to lower mortality [within first 10 weeks after liver transplantation] compared with standard isotonic intravenous glucose solution (low certainty).

1 finding from 1 review

Parenteral nutrition plus branched‐chain‐amino‐acid‐enriched formula vs standard isotonic intravenous glucose solution

Mortality [within first 10 weeks after liver transplantation] · adult patients after liver transplantation.

Parenteral nutrition plus branched‐chain‐amino‐acid‐enriched formula showed no clear difference in mortality [within first 10 weeks after liver transplantation] compared with standard isotonic intravenous glucose solution (low certainty).

1 finding from 1 review