Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

141 questions · 143 findings · 48 reviews

No studies found 25 · 17.5%GRADE not reported 9 · 6.3%Very low 36 · 25.2%Low 35 · 24.5%Moderate 31 · 21.7%High 7 · 4.9%

Intervention not reported

Secondary ‐ All‐cause mortality  · Patients with acute uncomplicated diverticulitis

The intervention showed no clear difference in secondary ‐ All‐cause mortality  (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).

1 finding from 1 review

Topical prophylaxis vs no topical prophylaxis

Overall mortality ‐ topical prophylaxis versus placebo or no treatment · adults receiving mechanical ventilation for at least 48 hours

Topical prophylaxis showed no clear difference in overall mortality ‐ topical prophylaxis versus placebo or no treatment compared with no topical prophylaxis (moderate certainty).

1 finding from 1 review

Levofloxacin vs usual care

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis caused by Staphylococcus aureus

It is very uncertain whether levofloxacin changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with standard treatment (very low certainty).

1 finding from 1 review

Glycopeptide (vancomycin or teicoplanin) plus aminoglycoside (gentamicin) vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis due to Staphylococcus aureus in drug abusers

The review found no eligible studies for this question.

1 finding from 1 review

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with infective endocarditis due to penicillin‐susceptible Streptococci

The review found no eligible studies for this question.

1 finding from 1 review

Fosfomycin plus imipenem vs vancomycin

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with vancomycin (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention probably leads to lower mortality in children with HIV infection ‐ co‐trimoxazole… (moderate certainty).

1 finding from 1 review