Cochrane · systematic review · CD009092
Antibiotics for uncomplicated diverticulitis
Dichman, M-L, Rosenstock, SJ, Shabanzadeh, DM · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
ColorectalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
9
No studies
12
Included studies
NR
No studies 12 · 57.1%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 28.6%Moderate 3 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison of observational management with antibiotics for acute uncomplicated diverticulitis
Population: Patients with acute uncomplicated diverticulitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days | RR 0.89 [0.3, 2.62] | 3 studies · 1329 participants | Low Downgraded: risk of bias, imprecision |
Primary ‐ Short‐term emergency surgery within 30 days | RR 0.47 [0.13, 1.71] | 3 studies · 1329 participants | Low Downgraded: risk of bias, imprecision |
Secondary ‐ Recurrence during | RR 1.01 [0.81, 1.25] | 2 studies · 1024 participants | Moderate Downgraded: risk of bias, imprecision |
Secondary ‐ Long‐term complications during | RR 1.08 [0.61, 1.93] | 2 studies · 1024 participants | Low Downgraded: risk of bias, imprecision |
Secondary ‐ Long‐term emergency surgery during | RR 1.42 [0.58, 3.49] | 2 studies · 1024 participants | Low Downgraded: risk of bias, imprecision |
Secondary ‐ All‐cause mortality  | RR 0.98 [0.6, 1.59] | 3 studies · 1262 participants | Moderate Downgraded: risk of bias, imprecision |
Secondary ‐ Adverse events | RR 0.14 [0.02, 1.13] | 3 studies · 1329 participants | Moderate Downgraded: risk of bias, imprecision |
Comparison of different antibiotic agents
Population: Patients with acute uncomplicated diverticulitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days | no estimate extracted | NR | No studies |
Primary ‐ Short‐term emergency surgery within 30 days | RR 0.7 [0.11, 4.58] | 1 study · 51 participants | Low Downgraded: risk of bias, imprecision |
Secondary ‐ Recurrence during | no estimate extracted | NR | No studies |
Secondary ‐ Long‐term complications during | no estimate extracted | NR | No studies |
Secondary ‐ Long‐term emergency surgery during | no estimate extracted | NR | No studies |
Secondary ‐ All‐cause mortality | no estimate extracted | NR | No studies |
Secondary ‐ Adverse events | no estimate extracted | NR | No studies |
Comparison of antibiotics for routes of administration and duration of therapy
Population: Patients with acute uncomplicated diverticulitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days | no estimate extracted | NR | No studies |
Primary ‐ Short‐term emergency surgery within 30 days | no estimate extracted | NR | No studies |
Secondary ‐ Recurrence during | no estimate extracted | NR | No studies |
Secondary ‐ Long‐term complications during | RR 1 [0.07, 15] | 1 study · 44 participants | Low Downgraded: risk of bias, imprecision |
Secondary ‐ Long‐term emergency surgery during | no estimate extracted | NR | No studies |
Secondary ‐ All cause mortality | no estimate extracted | NR | No studies |
Secondary ‐ Adverse events | no estimate extracted | NR | No studies |