Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

52 questions · 54 findings · 18 reviews · Gynaecology and Fertility

No studies found 8 · 14.8%GRADE not reported 0 · 0%Very low 24 · 44.4%Low 19 · 35.2%Moderate 2 · 3.7%High 1 · 1.9%

Summary of findings table ‐ ICSI vs c‐IVF

Miscarriage · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in miscarriage compared with c‐IVF (moderate certainty).

1 finding from 1 review

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Miscarriage · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in miscarriage rate per pregnancy compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Miscarriage per clinical pregnancy · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in miscarriage per clinical pregnancy compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Magnetic‐activated cell sorting (MACS) vs hyaluronic acid‐selected sperm (HA‐ICSI)

Miscarriage per clinical pregnancy · assisted reproduction

It is very uncertain whether magnetic‐activated cell sorting (MACS) changes miscarriage per clinical pregnancy compared with hyaluronic acid‐selected sperm (HA‐ICSI) (very low certainty).

1 finding from 1 review

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Miscarriage per clinical pregnancy · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes miscarriage per clinical pregnancy compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review