Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

280 questions · 284 findings · 102 reviews

No studies found 14 · 4.9%GRADE not reported 9 · 3.2%Very low 138 · 48.6%Low 62 · 21.8%Moderate 58 · 20.4%High 3 · 1.1%

Levomepromazine vs Typical antipsychotics

Leaving the study early ‐ long term ‐ due to adverse events · patients with schizophrenia

Levomepromazine showed no clear difference in leaving the study early ‐ long term ‐ due to adverse events compared with typical antipsychotics (moderate certainty).

1 finding from 1 review

DANCE THERAPY vs usual care

Clinical global response‐leaving the study early (long term) · patients with schizophrenia

DANCE THERAPY showed no clear difference in clinical global response‐leaving the study early (long term) compared with STANDARD CARE (low certainty).

1 finding from 1 review

Levomepromazine vs Typical antipsychotics

Withdrawals due to adverse events · patients with schizophrenia

Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ due to adverse events compared with typical antipsychotics (low certainty).

1 finding from 1 review

Levomepromazine vs atypical antipsychotics

Withdrawals due to adverse events · patients with schizophrenia

Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ due to adverse events compared with atypical antipsychotics (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Leaving the study early ‐ due to adverse effects (short term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in leaving the study early ‐ due to adverse effects (short term) compared with RESERPINE (moderate certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs other depot antipsychotic drugs

Leaving the study early ‐ short/medium term Rate of attrition · patients with schizophrenia or related psychoses

FLUPENTHIXOL DECANOATE showed no clear difference in leaving the study early ‐ short/medium term Rate of attrition compared with OTHER DEPOT ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE HIGH DOSE vs FLUPENTHIXOL DECANOATE STANDARD DOSE (˜40 mg/IM)

Leaving the study early ‐ short/medium term Rate of attrition · patients with schizophrenia or related psychoses

FLUPENTHIXOL DECANOATE HIGH DOSE may leads to lower leaving the study early ‐ short/medium term Rate of attrition compared with FLUPENTHIXOL DECANOATE STANDARD DOSE (˜40 mg/IM) (low certainty).

1 finding from 1 review

DANCE THERAPY vs usual care

Clinical global response‐leaving the study early (short term) · patients with schizophrenia

DANCE THERAPY showed no clear difference in clinical global response‐leaving the study early (short term) compared with STANDARD CARE (moderate certainty).

1 finding from 1 review

Technology‐mediated psychoeducation vs usual care

Leaving the study early · schizophrenia

It is very uncertain whether technology‐mediated psychoeducation changes compliance/satisfaction: leaving the study early ‐ any reason compared with standard care intervention (very low certainty).

1 finding from 1 review

Paliperidone palmitate vs placebo

Leaving the study early · patients with schizophrenia

Paliperidone palmitate leads to lower leaving the study early ‐ any reason Reported by trial author compared with placebo (high certainty).

1 finding from 1 review

RISPERIDONE vs QUETIAPINE

Leaving the study early · people with both severe mental illness and substance misuse

RISPERIDONE showed no clear difference in leaving the study early: 1. any reason, long term (>12 months) compared with QUETIAPINE ‒ short‐ and long‐term data (low certainty).

1 finding from 1 review

Levomepromazine vs atypical antipsychotics

Leaving the study early ‐ short term ‐ due to lack of efficacy · patients with schizophrenia

It is very uncertain whether levomepromazine changes leaving the study early ‐ short term ‐ due to lack of efficacy compared with atypical antipsychotics (very low certainty).

1 finding from 1 review

Levomepromazine vs Typical antipsychotics

Leaving the study early ‐ short term ‐ due to lack of efficacy · patients with schizophrenia

Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ due to lack of efficacy compared with typical antipsychotics (low certainty).

1 finding from 1 review

Cannabidiol vs AMISULPRIDE

Leaving the study early ‐ medium term ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

RISPERIDONE vs placebo

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

RISPERIDONE may leads to lower leaving the study early ‐ short term (up to 12 weeks) ‐ any reason compared with PLACEBO (low certainty).

1 finding from 1 review