Findings

What do systematic reviews say?

23 questions · 23 findings · 17 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 1 · 4.3%Very low 4 · 17.4%Low 11 · 47.8%Moderate 2 · 8.7%High 5 · 21.7%

Anti‐IL13 or anti‐IL4 agents vs placebo

Health‐related quality of life (AQLQ)Scale from: 1‐7 (higher is better) · people with asthma

1 finding from 1 review

Anti‐interleukin‐13 and anti‐interleukin‐4 agents versus placebo, anti‐interleukin‐5 or anti‐immunoglobulin‐E agents,… 2021 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 4960 participants
High

Mepolizumab intravenous (IV) vs placebo

Health‐related quality of life (AQLQ)Scale from: 1‐7 (higher is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 369 participants
High

Reslizumab intravenous (IV) vs placebo

Health‐related quality of life (AQLQ)Scale from: 1‐7 (higher is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1164 participants
High

Reslizumab subcutaneous (SC) vs placebo

Health‐related quality of life (AQLQ)Scale from: 1‐7 (higher is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 464 participants
High

Benralizumab subcutaneous (SC) vs placebo

Health‐related quality of life (AQLQ)Scale from: 1‐7 (higher is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1541 participants
High

Anti‐IL‐4Rα mAb (dupilumab) vs placebo (on top of topical steroids)

Generic quality of life measures · patients with severe chronic rhinosinusitis with nasal polyps

1 finding from 1 review

Biologics for chronic rhinosinusitis 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 766 participants
Moderate

Surgery vs splint

Health‐related quality of life (EQ‐5D) ‐ Long‐term improvement: > 3 months Scale: 0 to 1, higher is better · carpal tunnel syndrome

1 finding from 1 review

Surgical versus non‐surgical treatment for carpal tunnel syndrome 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 167 participants
Low

Summary of findings: insulin degludec vs insulin detemir

Health related quality of life the Uniscale and the Symptom Distress Scale (SDS); Better indicated by lower values

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 454 participants
Low

Summary of findings: insulin degludec vs insulin glargine

Health related quality of life the Uniscale and the Symptom Distress Scale (SDS); Better indicated by lower values

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1042 participants
Very low

Cognitive‐behavioural intervention vs controls

Health‐related quality of life end of treatment (0‐80 scale) Higher scores indicate lower health‐related quality of life · patients with fibromyalgia

1 finding from 1 review

Cognitive behavioural therapies for fibromyalgia 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 1238 participants
Low

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Self‐reported health‐related quality of life (0‐100 scale) Higher scores indicate higher burden of disease (lower quality of life) · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).

1 finding from 1 review

Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia 2018 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 6861 participants
Low

Parent‐only interventions vs minimal contact control

Health‐related quality of life (HRQoL) · children with overweight or obesity

1 finding from 1 review

Parent‐only interventions for childhood overweight or obesity in children aged 5 to 11 years 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 93 participants
GRADE not reported

Preoperative education vs usual care

Quality of Life: SF‐36 (physical component) · patients with knee replacement surgery

1 finding from 1 review

Preoperative education for hip or knee replacement 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 109 participants
Low

Intervention not reported

Health‐related quality of life SF‐36 scale: total score 0‐100, 8 subscales. Higher values mean better health‐related quality of life. · people at risk for development of T2DM

1 finding from 1 review

Dipeptidyl‐peptidase (DPP)‐4 inhibitors and glucagon‐like peptide (GLP)‐1 analogues for prevention or delay of type 2… 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1791 participants
Very low

Mobile bearing vs fixed bearing prosthesis

Health‐related quality of life (physical) · patients with posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients with osteoarthritis and…

1 finding from 1 review

Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for postoperative… 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 498 participants
Low

Intervention not reported

Health‐related quality of life (health status) COPD Assessment Tool. Scale from 0 to 5; higher score indicates worse HRQoL Contains 10 questions with 5‐point Likert scale · individuals with stable bronchiectasis

The intervention showed no clear difference in health‐related quality of life (health status) COPD Assessment Tool.… (low certainty).

1 finding from 1 review

Airway clearance techniques for bronchiectasis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Ventilation feedback training plus exercise vs exercise

Health‐related quality of life (Change in CRQ Dyspnoea) CRQ · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Breathing exercises for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 73 participants
Moderate

Intervention not reported

Health‐related quality of life (cough‐specific) Leicester Cough Questionnaire Scale from 0 to 133; higher score indicates better HRQoL. Contains 19 questions from 3 domains on a Likert scale · individuals with stable bronchiectasis

1 finding from 1 review

Airway clearance techniques for bronchiectasis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Eculizumab vs placebo

Health‐related quality of life European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ‐C30). Scale from: 0 to 100 (a higher score means a better outcome) · patients with paroxysmal nocturnal hemoglobinuria

1 finding from 1 review

Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Low

Intervention not reported

Health‐related quality of life (generic) SF‐36 (Mental Component Sumary (MCS) score) Scale from 0‐100 Higher value post intervention is favourable, indicating improvement in health‐related quality of life · people with stable COPD

1 finding from 1 review

Singing for adults with chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 52 participants
Low