Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

334 questions · 707 findings · 50 reviews

No studies found 3 · 0.4%GRADE not reported 667 · 94.3%Very low 31 · 4.4%Low 4 · 0.6%Moderate 2 · 0.3%High 0 · 0%

Significant salivary microbial (Lactobacillus) load vs No/low significant microbial load

Dental caries · Primary school children in Ethiopia

A significant salivary microbial (Lactobacillus) load was associated with higher odds of dental caries (OR 3.82, 95% CI 3.439-4.192; ungraded).

1 finding from 1 review

C allele vs T allele

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs10735810) C allele was significantly associated with higher caries risk vs T allele (pooled OR 1.33, 95% CI 1.03-1.71); ungraded.

1 finding from 1 review

CC+CT genotypes vs TT genotype

Dental caries · Children (<18 years) with vs without dental caries

CC+CT genotype at FokI(rs10735810) was associated with ~1.87-fold higher caries risk than TT (dominant model, OR 1.87); ungraded.

1 finding from 1 review

AA genotype vs AG+GG genotypes

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) recessive model: AA vs AG+GG was not significantly associated with dental caries (OR 1.09); ungraded.

1 finding from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported an OR of 1.32 when prenatal vitamin D was measured at 6 to 38 gestational weeks.

2 findings from 1 review

Absence of toothpaste use vs Toothpaste use

Dental caries · Primary school children in Ethiopia

Absence of toothpaste use was not significantly associated with dental caries (OR 1.42, 95% CI -1.278 to 4.109, p=0.3029; ungraded).

1 finding from 1 review

TT+CC (homozygous) genotypes vs TC (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

In the Real-time quantitative PCR genotyping subgroup, TaqI(rs731236) over-dominant model: TT+CC vs TC showed a significant association with caries (OR 1.52); ungraded.

8 findings from 1 review
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Grade level 1-4 (first cycle) vs Grade level 5 or above

Dental caries · Primary school children in Ethiopia

Being in grade levels 1-4 was associated with higher odds of dental caries (OR 2.46, 95% CI 1.523-3.397; ungraded).

1 finding from 1 review

High intake of sweets vs Lower/less intake of sweets

Dental caries · Primary school children in Ethiopia

A high intake of sweets was associated with higher odds of dental caries (OR 2.71, 95% CI 1.968-3.451; ungraded).

1 finding from 1 review

AA+AG genotypes vs GG genotype

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) dominant model: AA+AG vs GG was not significantly associated with dental caries (OR 1.07); ungraded.

1 finding from 1 review

CC+CA genotypes vs AA genotype

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) dominant model: CC+CA vs AA was not significantly associated with dental caries (OR 0.91); ungraded.

1 finding from 1 review

Cdx-2(rs11568820) A allele / genotype vs G allele

Dental caries · Children (<18 years) with vs without dental caries

Cdx-2(rs11568820) was reported by only one study and was not meta-analyzed; its association with caries risk is uncertain (ungraded).

1 finding from 1 review

TT+TG genotypes vs GG genotype

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) dominant model: TT+TG vs GG was not significantly associated with dental caries (OR 1.09); ungraded.

1 finding from 1 review

GG genotype vs GA+AA genotypes

Dental caries · Children (<18 years) with vs without dental caries

After removing Zhang 2006, the recessive model at BsmI(rs1544410) remained non-significant (OR 0.86); ungraded.

2 findings from 1 review

AA+GG (homozygous) genotypes vs GA (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

After removing Zhang 2006, the over-dominant model at BsmI(rs1544410) remained non-significant (OR 0.85); ungraded.

2 findings from 1 review

TT+GG (homozygous) genotypes vs TG (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) over-dominant model: TT+GG vs TG was not significantly associated with dental caries (OR 0.89); ungraded.

1 finding from 1 review

CC genotype vs CT+TT genotypes

Dental caries · Children (<18 years) with vs without dental caries

Recessive model (CC vs CT+TT) at FokI(rs10735810) showed no significant association with caries (OR 1.23, 95% CI 0.97-1.55); ungraded.

1 finding from 1 review

CC+AA (homozygous) genotypes vs CA (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) over-dominant model: CC+AA vs CA was not significantly associated with dental caries (OR 0.91); ungraded.

1 finding from 1 review

AA+GG (homozygous) genotypes vs AG (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) over-dominant model: AA+GG vs AG was not significantly associated with dental caries (OR 1.04); ungraded.

1 finding from 1 review

Prenatal vitamin D level ≤35 nmol/L vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported a slightly higher odds ratio at maternal prenatal vitamin D ≤35 nmol/L than at ≤50 nmol/L, without a numeric value in the available sources.

1 finding from 1 review