Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

36 questions · 36 findings · 17 reviews

No studies found 11 · 30.6%GRADE not reported 1 · 2.8%Very low 9 · 25%Low 13 · 36.1%Moderate 0 · 0%High 2 · 5.6%

IVIg vs placebo

Death · adults with renal vasculitis

Intravenous immunoglobulin showed no clear difference in death compared with placebo (low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Overall survival (risk of death) ‐ adults with myocarditis, median · adults with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes overall survival (risk of death) ‐ adults with myocarditis, median compared with placebo or no treatment (very low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Overall survival (risk of death) ‐ children with myocarditis, 6‐month · children with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes overall survival (risk of death) ‐ children with myocarditis, 6‐month compared with placebo or no treatment (very low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Event‐free survival (no death, transplant, or left ventricular assist device) ‐ adults with myocarditis · adults with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes event‐free survival (risk of death, cardiac transplant, or left… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Intravenous dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block

The review found no eligible studies for this question.

1 finding from 1 review

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

All‐cause mortality during hospital stay · adult patients after liver transplantation.

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes death (during length of initial hospital stay; ITT) compared with standard parenteral nutrition (very low certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Event‐free survival · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in event‐free survival with intravenous platinum (i.e. number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Mortality (in‐hospital death and 30‐day mortality) · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in mortality (in‐hospital death and 30‐day mortality) compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review