Cochrane · systematic review · CD009457
Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children
McNab, S, Ware, RS, Neville, KA, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 4 · 66.7%Moderate 0 · 0%High 1 · 16.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: children requiring intravenous fluid to maintain hydration
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hyponatraemia (serum sodium < 135 mmol/L) | RR 0.48 [0.38, 0.6] | 10 studies · 970 participants | High |
Hypernatraemia | RR 1.24 [0.65, 2.38] | 9 studies · 937 participants | Low |
Death | no estimate extracted | 10 studies · 996 participants | Low |
Seizures | RR 0.62 [0.03, 15.02] | 10 studies · 996 participants | Low |
Cerebral oedema | no estimate extracted | 9 studies · 9 participants | Very low |
Overhydration | RR 1.14 [0.46, 2.87] | 5 studies · 615 participants | Low |